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The Chemistry Behind Anticoagulants: An Intermediate's Journey

The development of effective anticoagulants, or blood thinners, has revolutionized the treatment and prevention of thrombotic events, significantly improving patient outcomes worldwide. These medications work by interfering with the body's complex clotting cascade. Understanding the chemistry behind these life-saving drugs often begins with the crucial role of specific chemical intermediates, such as 4,5,6,7-Tetrahydro-5-Methyl-Thiazolo[5,4-c]Pyridine-2-Carboxylic Acid Hydrochloride (CAS No. 720720-96-7).

At NINGBO INNO PHARMCHEM CO.,LTD., we are deeply involved in the early stages of this chemical journey, supplying high-quality intermediates that are essential for the synthesis of advanced pharmaceuticals. Our 4,5,6,7-Tetrahydro-5-Methyl-Thiazolo[5,4-c]Pyridine-2-Carboxylic Acid Hydrochloride is a key intermediate in the production of Edoxaban, a potent direct factor Xa (FXa) inhibitor. FXa is a critical enzyme in the coagulation pathway, and its inhibition by drugs like Edoxaban prevents the formation of blood clots.

The synthesis of Edoxaban, like many complex APIs, is a multi-step process. Each step requires precise chemical reactions, and the purity and structure of the intermediates are paramount to achieving the desired outcome. The 4,5,6,7-Tetrahydro-5-Methyl-Thiazolo[5,4-c]Pyridine-2-Carboxylic Acid Hydrochloride provides a specific structural motif that is indispensable for Edoxaban's pharmacological activity. Its thiazolopyridine core, combined with the carboxylic acid functionality, is strategically designed to fit into the active site of the FXa enzyme, thereby blocking its function.

The quality of this intermediate, typically supplied with a purity of over 98%, is a testament to NINGBO INNO PHARMCHEM CO.,LTD.'s commitment to excellence. We understand that any deviation in purity can lead to side reactions, reduced yields, and the potential introduction of impurities into the final drug product. This is why we implement rigorous analytical testing and quality control measures throughout our manufacturing processes, ensuring that our customers receive intermediates that meet the highest industry standards for efficacy and safety.

The development of new antithrombotic agents, including next-generation FXa inhibitors, relies on a consistent supply of well-characterized and high-purity intermediates. By providing essential components like 4,5,6,7-Tetrahydro-5-Methyl-Thiazolo[5,4-c]Pyridine-2-Carboxylic Acid Hydrochloride, NINGBO INNO PHARMCHEM CO.,LTD. plays a crucial role in enabling pharmaceutical companies to bring innovative treatments to patients who need them. Our focus on quality and reliability supports the entire drug development pipeline, from early-stage research to commercial manufacturing.

As the field of anticoagulation continues to evolve, the demand for sophisticated chemical intermediates that enable the creation of more targeted and effective therapies will only increase. NINGBO INNO PHARMCHEM CO.,LTD. is committed to being at the forefront of this evolution, providing the chemical foundations for the next generation of antithrombotic treatments.

Manufacturing Facilities

NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

Professional Export Experience

to Global Customers

WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

CONTACT US
Should you need to contact us; you may call during regular business hours, Monday through Friday, 8am – 6 pm.
NINGBO INNO PHARMCHEM CO.,LTD.
Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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