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The Chemistry Behind Apixaban: The Role of Ethyl 1-(4-Methoxyphenyl)...Intermediate

For R&D scientists engaged in pharmaceutical discovery and development, a deep understanding of synthetic pathways and the critical intermediates involved is fundamental. Apixaban, a highly effective direct factor Xa inhibitor, represents a significant advancement in anticoagulant therapy. Its synthesis is a complex process that relies on the precise assembly of specialized molecular fragments. Among these, Ethyl 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate (CAS: 503614-91-3) plays an indispensable role.

This compound, a sophisticated heterocyclic molecule, acts as a key precursor, embodying a significant portion of the final Apixaban structure. Its chemical name itself hints at the complexity of its structure, featuring a pyrazolopyridine core substituted with methoxyphenyl and oxopiperidinyl phenyl groups, along with an ethyl ester functionality. The successful synthesis and purification of this intermediate are critical for achieving the desired final product with high yield and purity. R&D scientists often require this compound for various purposes: validating synthesis routes, exploring structural analogues, or ensuring the availability of high-quality reference standards.

As a dedicated supplier of fine chemicals and pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. provides Ethyl 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate to researchers and manufacturers worldwide. We understand the scientific rigor behind pharmaceutical development and ensure our product's quality to support your research objectives. For those looking to buy this intermediate, we offer reliable sourcing, competitive pricing, and technical data to facilitate your work. Our commitment extends beyond mere supply; we aim to be a collaborative partner in your innovation journey. Exploring the synthesis of Apixaban often involves understanding the properties and sourcing of its key intermediates. We encourage R&D scientists to consider us as their trusted manufacturer for this and other vital building blocks, ensuring a consistent supply for both research and scale-up phases.

The ability to reliably purchase high-purity intermediates like CAS 503614-91-3 is essential for accelerating drug development timelines. NINGBO INNO PHARMCHEM CO.,LTD. is committed to providing the materials necessary for groundbreaking research and the efficient production of life-saving medications. Reach out to us to discuss your specific needs and how our products and expertise can support your scientific endeavors. We offer competitive price points and a robust supply chain, making us an ideal choice for your chemical sourcing requirements.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

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  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

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