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The Critical Role of Ethyl 6-(4-Aminophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate in Apixaban Manufacturing

In the intricate world of pharmaceutical manufacturing, the precise control and understanding of every chemical component are paramount. Among these, intermediates and impurities play a critical role, often dictating the efficacy, safety, and regulatory compliance of the final drug product. NINGBO INNO PHARMCHEM CO.,LTD. recognizes the profound importance of compounds like Ethyl 6-(4-Aminophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate, identified by its CAS number 503615-07-4.

This complex organic molecule, with the chemical formula C22H22N4O4 and a molecular weight of 406.43, serves as a crucial intermediate and a noted impurity in the synthesis pathway of Apixaban. Apixaban itself is a highly effective, direct, selective, and orally active inhibitor of coagulation factor Xa. Its therapeutic applications are significant, including the prevention of venous thromboembolism in patients undergoing orthopedic surgery, such as hip or knee replacements, and the treatment of stroke in patients with venous thromboembolic disorders or atrial fibrillation.

The precise chemical structure of Ethyl 6-(4-Aminophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate makes it an indispensable building block for achieving the desired molecular architecture of Apixaban. Pharmaceutical manufacturers rely on high-purity intermediates to ensure the successful synthesis of the active pharmaceutical ingredient (API). Furthermore, understanding and controlling impurities like this specific compound is a cornerstone of pharmaceutical quality assurance. Regulatory bodies worldwide mandate strict limits on impurities to guarantee the safety and efficacy of medicines.

For NINGBO INNO PHARMCHEM CO.,LTD., the availability of well-characterized pharmaceutical intermediates and reference standards is key to supporting global pharmaceutical innovation. Our commitment extends to providing materials that meet the highest standards, thereby assisting our clients in navigating the rigorous demands of drug development. The focus on compounds like Ethyl 6-(4-Aminophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate underscores our dedication to advancing healthcare through chemical expertise.

Beyond its role in established drug production, the study of such intermediates can also pave the way for future advancements. Researchers investigating novel oral coagulants or alternative therapeutic strategies may find value in understanding the chemical properties and synthetic routes associated with compounds like Ethyl 6-(4-Aminophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate. This deep dive into chemical compounds is what drives progress in the pharmaceutical industry.

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NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

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3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

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