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In the relentless pursuit of novel and effective pharmaceuticals, the precision of organic synthesis is paramount. Among the array of specialized reagents, tert-butanesulfinamide stands out as a critical tool for chemists, particularly in the realm of asymmetric synthesis. This organosulfur compound, identified by its CAS number 146374-27-8, has become a cornerstone for generating chiral amines with exceptional stereoselectivity. NINGBO INNO PHARMCHEM CO.,LTD. recognizes the profound impact of such reagents on drug development and is committed to providing high-quality materials to facilitate these advancements.
The primary utility of tert-butanesulfinamide lies in its function as a chiral auxiliary. It effectively acts as a chiral equivalent of ammonia, allowing for the stereoselective introduction of nitrogen-containing functionalities into organic molecules. This capability is crucial because the biological activity of many drugs is highly dependent on their specific stereochemistry. By employing tert-butanesulfinamide, researchers can control the formation of chiral centers, thereby synthesizing enantiomerically pure compounds with desired pharmacological properties. For instance, its use in the synthesis of pharmaceuticals like cetirizine exemplifies its importance in creating potent drug molecules.
The synthesis and application of tert-butanesulfinamide have been extensively studied and refined over the years. Its preparation involves well-established chemical processes, ensuring reliable supply for research and industrial needs. The resulting tert-butanesulfinamide intermediates, such as chiral sulfinimines, are more stable than conventional imines and exhibit predictable reactivity towards nucleophiles. This controlled reactivity, combined with the ease of removing the tert-butanesulfinyl group under acidic conditions, allows for the efficient isolation of chiral primary or secondary amines.
The demand for sophisticated chiral building blocks in the pharmaceutical industry continues to grow. Tert-butanesulfinamide plays a pivotal role in meeting this demand by enabling the cost-effective production of complex chiral amine intermediates. This contributes directly to the discovery and manufacturing of new therapeutic agents across various medical fields. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to supporting innovation by ensuring access to this vital chemical, thereby aiding in the development of next-generation medicines.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
