For procurement managers and R&D scientists in the pharmaceutical and chemical industries, understanding the pricing dynamics of critical intermediates is essential for budgeting and strategic planning. 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine (CAS 733039-20-8), a vital building block for advanced pharmaceuticals like CDK4 inhibitors, is no exception. Its price is a reflection of several interwoven factors, from raw material costs to the complexity of its synthesis and the rigorous quality control it undergoes.

One of the most significant determinants of price is purity. As a pharmaceutical intermediate, high purity is non-negotiable. Manufacturers invest heavily in advanced purification techniques and analytical instrumentation (e.g., HPLC, GC-MS, NMR) to ensure that compounds like 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine meet stringent standards, often exceeding 99%. The more demanding the purity requirements, the higher the associated production costs, which naturally translates to a higher price per kilogram or gram.

The complexity of the synthesis route itself also impacts cost. The multi-step process involved in creating 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine requires specific reagents, controlled reaction conditions, and skilled personnel. The cost of raw materials, energy consumption during manufacturing, and waste management all contribute to the overall production expense. Manufacturers with optimized synthetic pathways and efficient processes can offer more competitive pricing.

Production scale is another crucial factor. For bulk orders of 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine, manufacturers can often leverage economies of scale, reducing the per-unit cost. Conversely, smaller quantities required for early-stage research and development will typically have a higher price point due to the fixed costs associated with setting up and running production batches.

The reputation and reliability of the manufacturer also play a role. Established suppliers who have a proven track record of consistent quality, dependable delivery, and strong technical support may command a premium. Buyers are often willing to pay slightly more for the assurance of a secure supply chain and the peace of mind that comes with working with a trusted partner. When considering manufacturers in China, it is important to balance cost-effectiveness with quality assurances.

When seeking to buy 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine, buyers should obtain quotes from several reputable suppliers. It is advisable to compare not only the price but also the purity specifications, lead times, shipping terms, and the manufacturer's overall credibility. Understanding these factors will help in making an informed decision and securing this critical intermediate at a fair market price, ensuring the success of your pharmaceutical development projects.