In the intricate world of pharmaceutical manufacturing, the quality and availability of key intermediates are paramount. One such critical compound is 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine (CAS: 1350653-23-4). This heterocyclic molecule plays a vital role as a building block in the synthesis of Vericiguat, a significant drug used in the treatment of heart failure. Understanding its properties and sourcing strategies is essential for procurement managers and R&D scientists in the pharmaceutical sector.

What is 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine?

This compound, with the molecular formula C6H3FIN3 and a molecular weight of 263.01 g/mol, is characterized by its pyrazolo[3,4-b]pyridine core, substituted with a fluorine atom and an iodine atom. These specific functional groups make it an ideal precursor for complex organic syntheses, particularly in the pharmaceutical industry. Its high purity, typically above 98%, is crucial for ensuring the efficacy and safety of the final drug product.

The Significance in Vericiguat Synthesis

Vericiguat is a novel soluble guanylate cyclase (sGC) stimulator, approved for use in patients with symptomatic chronic heart failure with reduced ejection fraction. The synthesis pathway for Vericiguat heavily relies on precisely engineered chemical intermediates. 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine serves as a foundational element in this complex process. Its incorporation at an early stage ensures the correct stereochemistry and functional group placement required for the final API.

Sourcing from a Trusted Manufacturer in China

For pharmaceutical companies, securing a reliable supply of high-quality intermediates is a strategic imperative. China has emerged as a global hub for the production of fine chemicals and pharmaceutical intermediates. When seeking to purchase 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine, partnering with a reputable manufacturer in China like NINGBO INNO PHARMCHEM CO.,LTD. offers several advantages. These include competitive prices, stringent quality control measures, and the ability to scale production to meet demand. A good supplier will provide comprehensive product specifications, certificates of analysis (CoA), and reliable shipping solutions.

Key Considerations for Buyers

• Purity and Assay: Always verify the purity specifications, as even minor impurities can impact downstream reactions and final product quality.
• Packaging and Stability: The product is typically supplied in quantities ranging from milligrams to grams and requires appropriate packaging to maintain stability, often needing protection from light.
• Lead Time and Logistics: Understand the lead time for production and the available shipping methods to ensure uninterrupted supply for your manufacturing processes.
• Regulatory Compliance: Ensure the manufacturer adheres to relevant quality standards and can provide necessary documentation for regulatory submissions.

In conclusion, 5-fluoro-3-iodo-1H-pyrazolo[3,4-b]pyridine is an indispensable intermediate for the pharmaceutical industry, particularly for the synthesis of Vericiguat. By collaborating with experienced and quality-conscious suppliers and manufacturers in China, companies can ensure a consistent and cost-effective supply, thereby supporting the development and accessibility of life-saving medications.