In the intricate world of organic synthesis, specific building blocks are crucial for creating complex molecules with desired properties. Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid (CAS: 190190-48-8) is one such compound, widely recognized for its utility in medicinal chemistry and pharmaceutical research. This article delves into its structural features, synthetic applications, and where to purchase this vital intermediate.

Structural Features and Synthetic Utility

Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid is characterized by several key structural elements that make it highly valuable:

• N-Boc Protection: The tert-butyloxycarbonyl (Boc) group is a standard protecting group for amines. Its presence allows chemists to selectively perform reactions on other parts of the molecule without affecting the amine functionality. This protection is readily removed under acidic conditions, regenerating the free amine for further transformations.
• Chiral Center: The (R)-configuration at the alpha-carbon of the amino acid backbone is critical for applications where stereospecificity is required, such as in the synthesis of chiral drugs or biologically active peptides.
• Benzothienyl Moiety: The benzothiophene ring system provides a rigid, planar structure with aromatic and heterocyclic character. This moiety can influence the pharmacokinetic and pharmacodynamic properties of molecules into which it is incorporated, such as lipophilicity and receptor binding.

These features make Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid an excellent starting material or intermediate for a variety of synthetic pathways, particularly in the development of new pharmaceutical agents and complex organic molecules.

Applications in Research and Development

The primary applications for this compound lie in:

• Peptide Synthesis: As a modified amino acid, it can be incorporated into peptide chains to introduce specific structural features or functionalities.
• Medicinal Chemistry: It serves as a versatile building block for synthesizing potential drug candidates targeting various disease pathways. Researchers often use it to explore structure-activity relationships (SAR) due to its unique scaffold.
• Drug Discovery: Its inclusion in compound libraries can help identify new lead compounds with desirable biological activity.

Where to Buy and Sourcing Tips

When seeking to buy Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid, it’s essential to find a reliable supplier that guarantees quality and consistency. Searching for ‘Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid price’ will reveal various suppliers, often including manufacturers in China who offer competitive rates. It is advisable to request a Certificate of Analysis (COA) with each purchase to verify purity and specifications. For large-scale synthesis or ongoing research projects, establishing a relationship with a dependable manufacturer is crucial for ensuring a stable supply chain and obtaining the best possible price per kilogram.

In summary, Boc-(R)-3-amino-4-(3-benzothienyl)-butyric acid is a sophisticated chemical intermediate that plays a vital role in advancing organic synthesis and drug discovery. By understanding its properties and sourcing it wisely, researchers and chemical manufacturers can effectively drive innovation.