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High-dose methotrexate therapy is a powerful tool in treating various cancers, but it carries a significant risk of toxicity to healthy tissues. Levofolinic Acid serves as a vital rescue agent, a medical intervention designed to counteract these adverse effects. NINGBO INNO PHARMCHEM CO.,LTD. provides the high-quality Levofolinic Acid pharmaceutical raw material essential for the successful implementation of these critical 'leucovorin rescue' protocols.
Methotrexate is an antifolate agent that inhibits the enzyme dihydrofolate reductase (DHFR). This inhibition disrupts the synthesis of tetrahydrofolate, a coenzyme crucial for DNA and RNA synthesis. Consequently, rapidly dividing cells, including bone marrow and mucosal cells, are severely affected. Levofolinic Acid, being a biologically active form of folic acid that bypasses the DHFR enzyme, replenishes the reduced folate pool in healthy cells. This 'folinic acid rescue' or 'leucovorin rescue' effectively protects these cells from the cytotoxic effects of methotrexate. The precise Levofolinic Acid CAS 68538-85-2 ensures that clinicians are using the correct therapeutic agent for this protective role.
The administration of Levofolinic Acid in rescue protocols requires meticulous dosing and timing, tailored to the patient's methotrexate levels and excretion rate. Pharmaceutical manufacturers play a key role in providing a consistent supply of high-purity Levofolinic Acid powder to meet these demands. NINGBO INNO PHARMCHEM CO.,LTD. is a trusted source for this API, offering Levofolinic Acid that meets stringent pharmaceutical quality standards. Our adherence to such standards, including potential USP standards for Levofolinic Acid, ensures the reliability and safety of the medication produced from our raw material.
For healthcare providers and institutions, selecting a dependable supplier is paramount when needing to buy Levofolinic Acid powder for methotrexate rescue. NINGBO INNO PHARMCHEM CO.,LTD. is committed to supporting medical professionals by providing a consistent, high-quality supply of Levofolinic Acid. Our product's purity and quality are essential for the success of these life-saving protocols, safeguarding patients during intensive chemotherapy treatments.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
