Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
Cyclopamine (CAS 4449-51-8) is a steroidal alkaloid that has carved a significant niche in the scientific research landscape due to its potent inhibitory effects on the Hedgehog (Hh) signaling pathway. Understanding its scientific basis is crucial for researchers utilizing this compound.
The Hedgehog signaling pathway is a complex intercellular communication system vital for embryonic development. It regulates cell proliferation, differentiation, and pattern formation. When this pathway becomes aberrantly activated in adult tissues, it can lead to uncontrolled cell growth, contributing to the development and progression of various cancers. Cyclopamine's primary scientific role is to disrupt this pathway.
Specifically, Cyclopamine acts as a direct antagonist of the Smoothened (Smo) protein, a G protein-coupled receptor that is central to Hh signal transduction. By binding to Smo, Cyclopamine prevents its activation and subsequent downstream signaling events, including the activation of Gli transcription factors. This inhibition is critical for its biological effects, ranging from teratogenic outcomes in developmental studies to anti-cancer activities.
The scientific implications of Cyclopamine's mechanism are far-reaching. In developmental biology, its teratogenic properties have provided invaluable insights into the critical roles of the Hh pathway during embryonic development. For cancer research, its ability to inhibit tumor growth, particularly by targeting cancer stem cells, has positioned it as a promising agent for novel therapeutic strategies. Researchers looking to explore these complex biological processes can rely on a consistent supply of high-purity Cyclopamine from our company, a leading manufacturer and supplier in China. When you decide to buy Cyclopamine or seek to purchase CAS 4449-51-8, consider our commitment to scientific excellence and reliable sourcing. We offer competitive prices to support your research endeavors, ensuring you have access to this essential compound.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
