Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
Methotrexate (CAS 59-05-2) is a compound whose therapeutic significance is deeply rooted in its precise molecular action. As a structural analog of folic acid, it acts as a potent inhibitor of the enzyme dihydrofolate reductase (DHFR). This enzyme is indispensable for the conversion of dihydrofolate to tetrahydrofolate, a crucial cofactor for the synthesis of thymidylate and purines, which are the building blocks of DNA. By blocking this pathway, Methotrexate effectively arrests the de novo synthesis of DNA, thereby inhibiting the proliferation of rapidly dividing cells. This is the core of the methotrexate mechanism of action, making it a highly effective antimetabolite in chemotherapy.
The impact of this mechanism extends beyond cancer treatment. In lower doses, Methotrexate exhibits immunosuppressive and anti-inflammatory properties, making it a cornerstone in managing autoimmune diseases such as rheumatoid arthritis, psoriasis, and Crohn's disease. It influences various immune cells and cytokines, helping to control the aberrant immune responses characteristic of these conditions. The success of Methotrexate in these therapeutic areas is well-documented, with ongoing studies exploring its potential in new applications. Understanding the methotrexate uses in these varied contexts highlights its versatility.
However, the potent nature of Methotrexate also necessitates careful consideration of its safety profile. Potential methotrexate side effects, including gastrointestinal distress, bone marrow suppression, and liver toxicity, underscore the importance of proper medical supervision and adherence to recommended methotrexate dosage. Patients must be informed about possible methotrexate drug interactions and the critical methotrexate pregnancy warning, which prohibits its use during pregnancy due to severe teratogenic effects. For those seeking to buy Methotrexate for research or therapeutic purposes, understanding these scientific underpinnings ensures responsible use.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
