Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
The journey from raw materials to life-saving pharmaceuticals is complex, relying heavily on precisely engineered chemical intermediates. Among these, (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine ((2R,3R)-2,3-bis((4-methylbenzoyl)oxy)succinate) (2:1), identified by CAS number 477600-71-8, holds significant importance as a key building block for the drug Tofacitinib.
The synthesis of CAS 477600-71-8 is a testament to advanced organic chemistry. It involves a series of carefully controlled reactions designed to construct the specific molecular architecture and stereochemistry required for its function as a Tofacitinib precursor. This process often demands specialized reagents, catalysts, and precise reaction conditions to ensure high yields and enantiomeric purity. Pharmaceutical intermediate manufacturers invest heavily in research and development to optimize these synthetic routes, aiming for efficiency, scalability, and cost-effectiveness.
The primary application of CAS 477600-71-8 lies in its role as a crucial intermediate in the multi-step synthesis of Tofacitinib. Tofacitinib is a Janus kinase (JAK) inhibitor, widely used in treating autoimmune conditions such as rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. The structural integrity and purity of the intermediate directly influence the purity and efficacy of the final Active Pharmaceutical Ingredient (API). Therefore, companies that manufacture or utilize this intermediate must adhere to stringent quality standards.
For businesses looking to buy this critical intermediate, understanding the supply chain is key. Reputable chemical manufacturers, many of whom are based in China, offer CAS 477600-71-8 with guaranteed purity levels and detailed technical documentation. Engaging with these suppliers ensures access to a consistent and reliable source, facilitating the uninterrupted production of Tofacitinib. The continuous demand for such advanced intermediates underscores the dynamic nature of the pharmaceutical chemical industry and the vital role of skilled manufacturers in bringing essential medicines to patients worldwide.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
