Custom Manufacturing, Project Outsourcing, your Trusted Partner from China
The selective modification of proteins is a cornerstone of modern biochemistry and biotechnology. Among the most versatile tools for this purpose is maleimide chemistry, which leverages the high reactivity of maleimide groups towards sulfhydryl (thiol) residues present in proteins. This specific reactivity allows for precise labeling, crosslinking, and conjugation of proteins, forming stable thioether linkages.
Maleimides act as electrophilic reagents, undergoing a Michael addition reaction with the thiolate anion of cysteine residues. This reaction is highly specific, generally occurring optimally at pH ranges between 6.5 and 7.5. The resulting thioether bond is remarkably stable and resistant to hydrolysis and reducing agents, making it ideal for applications where a permanent linkage is required. This specificity is particularly valuable in research involving heterobifunctional crosslinkers like 6-(BETA-Maleimidopropionamido)hexanoic acid (SMPH), where the maleimide end is designed to react with thiols.
Researchers often need to introduce thiol groups into molecules for subsequent conjugation with maleimides. Alternatively, proteins naturally containing cysteine residues can be directly targeted. For those looking to buy SMPH crosslinker, understanding the maleimide-thiol conjugation is key to its effective use. NINGBO INNO PHARMCHEM CO.,LTD., a leading manufacturer in China, provides high-purity maleimide-containing compounds and other fine chemical intermediates essential for these processes.
The price of maleimide derivatives and other conjugation reagents is an important consideration for budget-conscious research projects. As a reliable supplier, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive pricing without compromising on the quality and purity of its products. Whether you are performing protein labeling, developing ADCs, or studying protein-protein interactions, mastering thiol chemistry with maleimides is a critical skill. Rely on NINGBO INNO PHARMCHEM CO.,LTD. for your supply needs.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
