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In the demanding field of pharmaceutical and chemical research, the efficiency and purity of synthesis processes are paramount. NINGBO INNO PHARMCHEM CO.,LTD. is proud to highlight a cornerstone product for advanced chemical synthesis: TOTU, a highly effective uronium-based coupling reagent.
What is TOTU?
TOTU, with the CAS No. 136849-72-4, is chemically known as O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate. It presents as a high-purity (≥99%) white crystalline powder. As a coupling reagent, its primary function is to facilitate the formation of amide bonds, which is a fundamental step in the synthesis of peptides and other complex organic molecules. The molecular formula of TOTU is C₁₀H₁₇BF₄N₄O₃.
Advantages in Synthesis
The use of TOTU offers several distinct advantages over other coupling reagents. Its high reactivity allows for rapid and efficient coupling, even with sterically hindered amino acids, which can be challenging for other reagents. A key benefit of TOTU is its ability to suppress racemization, ensuring the chiral integrity of the final peptide product is maintained.
Furthermore, TOTU is recognized for its favorable safety profile, being less explosive and having lower allergenic potential compared to some traditional benzotriazole-based reagents like HBTU. Another significant practical advantage is that the by-products generated during the coupling reaction are water-soluble. This simplifies the post-reaction workup and purification process, making it an ideal choice for both solution-phase and solid-phase peptide synthesis (SPPS).
Key Applications
The primary application of TOTU is as a reagent in peptide synthesis. Peptides are crucial in drug discovery, biochemistry, and materials science. The ability of TOTU to create strong, stable amide bonds efficiently makes it an invaluable tool for researchers and developers creating novel therapeutic peptides or complex biomolecules. Its utility also extends to the synthesis of peptide nucleic acids (PNAs) and other organic compounds where the formation of an amide linkage is a critical step.
As a dedicated manufacturer and supplier of high-quality pharmaceutical intermediates, NINGBO INNO PHARMCHEM CO.,LTD. provides researchers and industrial clients with reliable access to premium-grade TOTU. For those looking to buy this essential coupling reagent, we offer consistent quality and a competitive price. To make a purchase or to inquire further about our product specifications, please contact our expert team.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
