Toxicology is the scientific discipline dedicated to understanding the adverse effects of chemical, physical, or biological agents on living organisms. A fundamental aspect of toxicology research is elucidating the mechanisms by which these agents cause harm at the cellular and molecular levels. This often involves investigating how toxins disrupt essential cellular processes, leading to stress, damage, and ultimately, cell death. The mitochondrion, as the primary site of cellular energy production and a key player in apoptosis, is frequently a target for toxic insults.

Understanding how various compounds affect mitochondrial function is crucial for assessing their toxicity. Researchers often employ specific chemical probes to mimic or induce cellular stress, allowing them to study the body's response and identify potential biomarkers of toxicity. These probes enable a controlled approach to dissecting complex toxicological pathways.

Atractyloside Sodium Salt (CAS 100938-11-2) serves as a potent example of such a tool in toxicology research. By specifically inhibiting the mitochondrial adenine nucleotide translocase (ANT), this compound disrupts the critical exchange of ADP and ATP across the mitochondrial inner membrane. This disruption leads to a significant reduction in ATP production, causing widespread cellular energy depletion and oxidative stress. Furthermore, it can induce mitochondrial membrane permeabilization, a key event that triggers the release of pro-apoptotic factors and the activation of cell death pathways.

The use of Atractyloside Sodium Salt in toxicological studies allows researchers to:

• Investigate energy metabolism disruption: Study how specific toxins interfere with ATP synthesis and cellular respiration by comparing their effects with known ANT inhibitors.
• Model mitochondrial dysfunction: Induce mitochondrial stress in a controlled manner to understand its role in various toxicities, such as hepatotoxicity or cardiotoxicity.
• Examine apoptosis as a mechanism of toxicity: Determine if a tested agent induces cell death via the mitochondrial pathway, often triggered by energy crisis.
• Screen for protective agents: Test compounds that might mitigate the toxic effects of energy depletion or mitochondrial damage.

For toxicologists and researchers in related fields, securing reliable and high-quality reagents is vital for the integrity of their studies. As a manufacturer and supplier of specialized chemicals, we provide Atractyloside Sodium Salt for research purposes. Our commitment to quality ensures that researchers can buy a consistent product that accurately models mitochondrial stress. We invite you to consider us as your trusted supplier for toxicology research tools, offering competitive pricing and dependable delivery from our facilities in China. Contact us to learn more about our product offerings and how we can support your critical toxicological investigations.