Trifluoromethanesulfonyl Chloride: A Cornerstone in Modern Chemical Synthesis

Trifluoromethanesulfonyl chloride (CF3SO2Cl), commonly known as triflyl chloride or TfCl, stands as a highly reactive and exceptionally versatile reagent in the realm of organic synthesis. This indispensable compound is a clear, colorless to pale-yellow liquid, recognized for its potent electrophilic nature and its critical role in introducing the triflyl (SO2CF3) group into various organic molecules. With a molecular formula of CF3ClO2S and a molecular weight of 168.52 g/mol, Trifluoromethanesulfonyl Chloride exhibits precise physical properties, including a boiling point typically ranging from 29 to 32 degrees Celsius and a density of approximately 1.58 g/cm³ at 25 degrees Celsius. While it reacts with water, it demonstrates good solubility in a range of organic solvents such as dichloromethane (DCM) and tetrahydrofuran (THF), making it adaptable for diverse reaction conditions.

The significance of Trifluoromethanesulfonyl Chloride spans across multiple high-value industries, cementing its status as a key chemical intermediate. In the pharmaceutical sector, it is pivotal for synthesizing complex drug molecules and essential intermediates, contributing to the development of novel therapeutics. Its utility extends to agrochemicals, where it facilitates the creation of advanced crop protection agents. Beyond these, TfCl plays a crucial role in the development of cutting-edge advanced materials, including specialized polymers, high-performance coatings that demand exceptional thermal and chemical resistance, and innovative electrolyte formulations vital for enhancing the efficiency and longevity of modern batteries. Its broad applicability underscores its importance in driving innovation in chemistry.

One of the primary applications of Trifluoromethanesulfonyl Chloride lies in the efficient synthesis of trifluoromethanesulfonate (triflate) esters. These triflate esters are renowned as excellent leaving groups, indispensable for a wide array of cross-coupling reactions, including but not limited to Suzuki, Heck, and Stille reactions. Furthermore, TfCl acts as a strong electrophile in Friedel-Crafts reactions and is employed as a halide remover in palladium-catalyzed processes. Recent research also highlights its utility in transition metal-free direct trifluoromethylthiolation of indoles and in the production of zinc sulfinate salts, showcasing its continuous relevance in evolving synthetic methodologies. Its high purity, often exceeding 98.5%, ensures reliable and consistent performance in demanding chemical reactions.

Given its high reactivity, Trifluoromethanesulfonyl Chloride requires careful handling and storage under controlled conditions, typically at 2-8 degrees Celsius under an inert gas atmosphere to maintain its integrity and prevent degradation. At NINGBO INNO PHARMCHEM CO.,LTD., we are committed to providing top-quality Trifluoromethanesulfonyl Chloride, ensuring that every batch meets stringent purity and specification standards. As a trusted chemical manufacturer and supplier, we understand the critical need for reliable and high-grade raw materials in your research and production processes. Our commitment to quality assurance is unwavering, backed by comprehensive testing and robust quality control systems.

For those looking to buy or purchase Trifluoromethanesulfonyl Chloride, NINGBO INNO PHARMCHEM CO.,LTD. offers competitive price options and flexible packaging solutions to meet diverse customer requirements, from laboratory-scale research to industrial production. We pride ourselves on efficient logistics and dedicated customer support, ensuring a seamless procurement experience. Whether you require a small quantity for experimental work or bulk supply for large-scale manufacturing, connect with us to discuss your specific needs. Partner with NINGBO INNO PHARMCHEM CO.,LTD. for your Trifluoromethanesulfonyl Chloride requirements and experience the excellence of a leading chemical supplier.