In the complex landscape of pharmaceutical synthesis, high-quality intermediates are the foundational building blocks that enable the creation of life-saving active pharmaceutical ingredients (APIs). Among these, 1-Boc-4-(6-Aminopyridin-3-Yl) Piperazine, identified by its CAS number 571188-59-5, stands out as a particularly significant compound. This chemical entity is a crucial intermediate in the multi-step synthesis route of Palbociclib, a widely recognized and effective targeted therapy for certain types of breast cancer.

Known by several synonyms, including Tert-Butyl 4-(6-Aminopyridin-3-yl)Piperazine-1-Carboxylate, this intermediate possesses a well-defined chemical structure with the formula C14H22N4O2 and a molecular weight of 278.35. It typically presents as a powder, a common physical form for pharmaceutical intermediates, facilitating ease of handling and precise measurement in synthesis processes. Key physical characteristics such as its melting point, reported around 130-132ºC, and its predicted boiling point and density are critical parameters for process development and quality control during its use.

The primary importance of 1-Boc-4-(6-Aminopyridin-3-Yl) Piperazine lies in its role as a prerequisite compound for manufacturing Palbociclib. Palbociclib is a cyclin-dependent kinase (CDK) 4/6 inhibitor, a class of drugs that targets specific enzymes involved in cell division. By selectively inhibiting these kinases, Palbociclib helps to slow down the progression of certain cancers, notably hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. The efficacy and safety of Palbociclib are directly linked to the purity and quality of the intermediates used in its production.

The synthesis of complex APIs like Palbociclib involves a series of precise chemical reactions, often requiring specific catalysts, controlled temperatures, and rigorous purification steps. 1-Boc-4-(6-Aminopyridin-3-Yl) Piperazine is typically introduced at a specific stage, contributing a significant portion of the final molecule's structural framework. Ensuring the purity and structural integrity of this intermediate at the outset is paramount to minimizing impurities in the final API, which could impact its efficacy, safety, and regulatory approval.

Manufacturing pharmaceutical intermediates requires adherence to stringent quality standards. Facilities producing compounds like CAS 571188-59-5 must operate under conditions that prevent contamination and ensure lot-to-lot consistency. Analytical methods such as High-Performance Liquid Chromatography (HPLC), Gas Chromatography (GC), Nuclear Magnetic Resonance (NMR) spectroscopy, and Mass Spectrometry (MS) are routinely employed to confirm the identity, purity, and impurity profile of the intermediate. These tests are essential for verifying that the product meets the required specifications for subsequent synthesis steps and ultimately for the final API.

The demand for high-quality pharmaceutical intermediates like 1-Boc-4-(6-Aminopyridin-3-Yl) Piperazine is driven by the global market for Palbociclib and similar targeted therapies. As more patients benefit from these advanced treatments, the need for reliable sources of their chemical precursors grows. This places a significant emphasis on selecting trustworthy manufacturers and suppliers who can consistently deliver product meeting the stringent quality requirements of the pharmaceutical industry.

When seeking to buy or purchase this intermediate, stakeholders in the pharmaceutical supply chain must consider various factors. Beyond just the chemical specifications, considerations include the manufacturer's quality management systems, regulatory compliance history (such as GMP standards), production capacity, technical support availability, and supply chain reliability. The price of the intermediate is, of course, a factor, but it must always be evaluated in conjunction with the assurance of quality, as substandard materials can lead to costly failures or delays in API production.

For researchers and pharmaceutical companies looking to secure a supply of high-purity 1-Boc-4-(6-Aminopyridin-3-Yl) Piperazine (CAS 571188-59-5), engaging with experienced manufacturers is key. Understanding the production scale capabilities of a potential supplier is also vital to ensure they can meet current and future demand. Information on lead times, packaging options, and shipping procedures should also be clarified before finalizing a purchase agreement. Obtaining samples for internal evaluation is a standard practice to confirm the quality before committing to larger orders. NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing reliable information regarding pharmaceutical raw materials and intermediates, assisting professionals in making informed sourcing decisions.