In the intricate world of organic chemistry, specific reagents play pivotal roles in enabling complex synthetic transformations. One such compound is 1-Chloro-2-iodoethane (CAS 624-70-4), a versatile halogenated hydrocarbon that serves as a crucial intermediate in various chemical processes. Understanding its properties and applications is key for researchers and formulators seeking to enhance their synthetic capabilities.

Chemical Profile of 1-Chloro-2-iodoethane

1-Chloro-2-iodoethane, also known by synonyms such as 2-iodoethyl chloride, is characterized by its molecular formula C2H4ClI and a molecular weight of 190.41 g/mol. It exists as a liquid, typically appearing colorless to light yellow or light orange. Its boiling point is approximately 61-62°C at 30 mmHg, and it has a density of 2.088 g/cm³. Importantly, this compound is light-sensitive, requiring storage in the dark, typically at refrigerated temperatures (0-10°C). Its solubility in inorganic solvents is good, while it is insoluble in water.

Synthetic Utility and Applications

The primary utility of 1-Chloro-2-iodoethane lies in its role as a mild electrophile. It is particularly effective in the iodination of metallated species, a process vital for converting compounds like ortho-lithiated benzyl ethers into their corresponding ortho-iodide derivatives. This capability makes it an indispensable tool for chemists engaged in intricate synthesis, especially within the pharmaceutical and agrochemical sectors.

Beyond iodination, it reacts with compounds like 5-hydroxy-[1,4]naphthoquinone to yield 5-(2-chloro-ethoxy)-[1,4]naphthoquinone, showcasing its potential in creating functionalized organic molecules. For researchers looking to buy this chemical for specific synthetic routes, understanding its reactivity profile is paramount.

Preparation and Safety Considerations

The preparation of 1-Chloro-2-iodoethane can involve several methods, often starting from ethylene or related precursors. Purification typically involves washing with thiosulfate solutions and distillation under reduced pressure to remove impurities and ensure the required quality for its intended use.

Safety is a critical aspect when handling 1-Chloro-2-iodoethane. As a dialkylating agent, it should only be used in a well-ventilated fume hood. Avoiding inhalation of vapors and direct skin contact is essential. Precautionary statements and hazard symbols (GHS07, signal word Warning) highlight the need for appropriate personal protective equipment and safe handling procedures.

Sourcing High-Quality 1-Chloro-2-iodoethane from China

For businesses and research institutions, securing a reliable supply of high-purity 1-Chloro-2-iodoethane is crucial. When you decide to buy chemical intermediates, partnering with a reputable manufacturer in China offers distinct advantages, including competitive pricing and consistent quality. Companies specializing in fine chemical manufacturing can provide the necessary certifications and support, ensuring that your procurement process is seamless. Whether you are looking for small research quantities or bulk industrial supply, exploring options from established suppliers is a wise strategic move.

In conclusion, 1-Chloro-2-iodoethane is a valuable reagent with specific applications in organic synthesis. Its unique properties, coupled with careful handling and strategic sourcing, make it an important component in the development of novel chemical products.