In the dynamic landscape of the chemical industry, a thorough understanding of compound properties is fundamental for successful application and sourcing. 2-Thioadenosine, identified by CAS number 43157-50-2, is a compound of considerable interest, particularly within the pharmaceutical and fine chemical sectors. This article provides a detailed chemical profile, offering essential data for industry professionals, including R&D scientists, chemists, and procurement specialists.

The molecular identity of 2-Thioadenosine is defined by its chemical formula, C₁₀H₁₃N₅O₄S, and a molecular weight of approximately 299.31 g/mol. This structure is characterized by a purine ring system, specifically a derivative of adenosine where the oxygen atom at the 2-position of the adenine base has been replaced by a sulfur atom. This modification is significant, impacting the compound's chemical reactivity and biological interactions. Its IUPAC name is 6-amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purine-2-thione, and it is also known by synonyms such as 2-Mercaptoadenosine and 2,3-Dihydro-2-thioxoadenosine. Understanding these synonyms is crucial when searching for suppliers and technical literature.

Key physical and chemical properties of 2-Thioadenosine are vital for its handling and application. It typically presents as a pale yellow to yellow solid. Its melting point is reported to be greater than 178°C with decomposition. While specific solubility data can vary, it is generally described as slightly soluble in aqueous base and DMSO, and slightly soluble in methanol, often requiring heating and sonication for dissolution. The density is approximately 2.18 g/cm³, and its pKa is around 8.37. Storage recommendations often include keeping it protected from light at temperatures between 2-8°C for short-term storage, or at -20°C for longer preservation, particularly in its powdered form.

The synthesis of 2-Thioadenosine is a topic of interest for chemical manufacturers and process chemists. One common synthetic route involves the reaction of carbon disulfide with appropriate imidazole derivatives or related precursors in solvents like tetrahydrofuran and methanol, often under elevated temperatures. The process requires careful control of reaction conditions to achieve high yields and purity. For example, a general procedure might involve heating the reactants in a mixture of solvents, followed by purification steps such as washing with ethanol and water. The yield is typically reported to be around 80% for such methods.

The primary industrial application driving the demand for 2-Thioadenosine is its role as a critical intermediate in the pharmaceutical industry, particularly for the synthesis of Cangrelor. However, its structure also makes it a subject of interest in biochemical research, where its effects on nucleic acid metabolism and cellular signaling pathways are studied. Professionals seeking to buy 2-Thioadenosine for these purposes will find it available from numerous chemical suppliers, with a significant portion of these manufacturers and suppliers located in China, offering competitive pricing and bulk availability.

In summary, a comprehensive understanding of 2-Thioadenosine's chemical structure, physical properties, and synthesis pathways is essential for its effective utilization in the chemical and pharmaceutical industries. As a key intermediate and a subject of research, its availability from reliable global manufacturers ensures continued progress in drug development and scientific discovery.