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Understanding 4-Chloroaniline (CAS 106-47-8): Properties and Purity for Synthesis

For chemists and formulators engaged in pharmaceutical research and development, a thorough understanding of the raw materials used is essential. 4-Chloroaniline, identified by its CAS number 106-47-8, is a key organic compound frequently employed as a pharmaceutical intermediate. Delving into its properties ensures optimal use in synthesis.

The chemical structure of 4-Chloroaniline, with the molecular formula C6H6ClN, features an amine group attached to a benzene ring, with a chlorine atom at the para position. This specific arrangement dictates its reactivity and suitability for various synthesis pathways. Understanding its molecular weight (127.57) is crucial for stoichiometric calculations in reaction planning. Physically, it typically presents as a white solid, with a melting point range of 67-70 °C and a boiling point of 232 °C, indicating its stability under standard laboratory and industrial conditions.

The most critical parameter for its use as a pharmaceutical intermediate is its purity. Manufacturers typically guarantee an assay of 99.5% minimum. This high level of purity minimizes the presence of unwanted by-products in subsequent reactions, which is vital for meeting the stringent quality requirements of the pharmaceutical industry. Impurities can affect reaction yields, product efficacy, and safety profiles of the final drug product.

For R&D scientists and purchasing managers, verifying the purity of 4-Chloroaniline from a supplier is a non-negotiable step. Requesting detailed specifications and Certificates of Analysis is standard practice. When considering where to buy this compound, look for suppliers who clearly state their quality standards and provide reliable product data. We are committed to supplying 4-Chloroaniline (CAS 106-47-8) with the purity and quality that your pharmaceutical projects demand. Contact us to inquire about pricing and place an order for this essential chemical.

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