In the intricate world of chemical synthesis and biopharmaceutical development, specific molecules act as critical building blocks, enabling groundbreaking innovations. One such compound is AEEA-AEEA, also known by its chemical name 17-Amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecanoic acid (CAS 1143516-05-5). This highly functionalized polyethylene glycol (PEG) derivative has garnered significant attention for its utility in diverse applications, particularly in advanced peptide synthesis and the creation of potent bioconjugates like Antibody-Drug Conjugates (ADCs) and Proteolysis Targeting Chimeras (PROTACs).

AEEA-AEEA is characterized by its white to off-white powder appearance and a purity level of typically 98.0% or higher. Its structure features a PEG chain with multiple ether linkages, terminated by an amine group on one end and a carboxylic acid group on the other. This bifunctional nature makes it an exceptionally versatile linker. The PEG chain itself imparts desirable hydrophilic properties, which can significantly enhance the solubility and bioavailability of the molecules it is conjugated to. This is a crucial factor when developing therapeutic agents that need to perform effectively in biological systems.

The primary applications for AEEA-AEEA lie in areas requiring precise molecular construction. In peptide synthesis, it acts as a valuable linker, allowing researchers to modify peptides to improve their therapeutic profiles. Its use is particularly pronounced in the field of ADCs, where it serves as a non-cleavable linker connecting the antibody to the cytotoxic drug payload. This non-cleavable nature ensures stability and controlled release of the drug at the target site. Similarly, AEEA-AEEA is employed in the synthesis of PROTACs, acting as a flexible linker between the target protein binder and the E3 ligase binder, facilitating efficient protein degradation pathways.

For scientists and procurement specialists, sourcing high-quality AEEA-AEEA is paramount. The purity and consistency of this intermediate directly impact the success of downstream applications. When you decide to buy AEEA-AEEA, it is imperative to partner with a reliable manufacturer and supplier. Companies like NINGBO INNO PHARMCHEM CO.,LTD. are dedicated to providing high-purity chemical intermediates, ensuring that their products meet stringent quality standards. This commitment translates to dependable performance in your sensitive synthesis processes.

When evaluating AEEA-AEEA price points, it’s important to consider the overall value proposition, which includes not only the cost per gram but also the guaranteed purity, batch-to-batch consistency, and the reliability of supply. Choosing a trusted supplier from China can often provide a balance of high quality and competitive pricing, making advanced chemical synthesis more accessible. By understanding the critical role of AEEA-AEEA as a chemical intermediate for drug discovery, you can make informed decisions to support your research objectives.

In essence, AEEA-AEEA is a pivotal chemical entity enabling significant advancements in bioconjugation and targeted therapeutics. Its unique properties and broad applicability make it an essential component for researchers pushing the boundaries of drug development. Ensuring a reliable supply of high-purity AEEA-AEEA from a reputable manufacturer is key to unlocking its full potential.