In the intricate world of organic chemistry, specific building blocks are indispensable for the creation of advanced molecules. Tert-boc-aminooxyacetic acid, widely known as Boc-AOA and identified by its CAS number 42989-85-5, is a prime example of such a critical chemical intermediate. Its versatile structure and controlled reactivity make it a favored reagent among research scientists and procurement specialists involved in peptide synthesis, drug development, and various other fine chemical applications. Understanding its properties and sourcing reliable supplies are key for any organization looking to advance its chemical research or manufacturing capabilities.

Boc-AOA is characterized by the presence of a tert-butyloxycarbonyl (Boc) protecting group attached to an aminooxyacetic acid backbone. This Boc group serves a vital purpose by masking the amine functionality, thereby controlling its reactivity and ensuring selective reactions at other sites on the molecule. The aminooxy group itself is highly reactive towards carbonyl compounds (aldehydes and ketones), readily forming stable oxime linkages. This specific reactivity profile makes Boc-AOA exceptionally useful in several key areas:

• Peptide Synthesis: It acts as a crucial component for introducing modified amino acid residues or creating peptide conjugates with unique structural features. Researchers often seek this reagent to build complex peptide libraries or develop novel peptide-based therapeutics.
• Drug Development: Boc-AOA is employed as a building block in the synthesis of various drug candidates. Its ability to form oximes is leveraged in prodrug strategies, targeted delivery systems, and in the synthesis of complex heterocyclic compounds that form the core of many pharmaceuticals.
• Bioconjugation: Its role in forming stable oxime bonds makes it a valuable tool for linking biomolecules to other entities, such as labels, solid supports, or drug payloads. This is essential in fields like diagnostics, affinity purification, and the creation of antibody-drug conjugates (ADCs).

For any laboratory or manufacturing facility, the quality of chemical intermediates like Boc-AOA is non-negotiable. A high purity level, typically u226598% by HPLC, ensures predictable reaction outcomes and minimizes the risk of impurities interfering with sensitive synthetic pathways. Therefore, when planning to buy Boc-AOA, it is imperative to source it from reputable chemical manufacturers and suppliers. Companies specializing in fine chemicals, particularly those with robust quality control systems and a global presence, can offer consistent product quality and reliable supply chains, often at competitive price points, especially for bulk purchases.

In essence, Boc-aminooxyacetic acid (CAS 42989-85-5) is more than just a chemical compound; it is an enabler of sophisticated chemical innovation. By understanding its properties and ensuring access to high-purity supplies from trusted manufacturers, researchers and developers can effectively harness its potential in their critical projects, from advancing peptide synthesis to discovering the next generation of pharmaceuticals.