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In the realm of biochemical research and pharmaceutical development, specific amino acid derivatives serve as foundational tools for constructing complex molecules with targeted functions. Boc-D-His(Tos)-OH·DCHA is one such derivative, offering unique chemical characteristics that make it indispensable for a variety of advanced applications, particularly in peptide synthesis.
At its core, Boc-D-His(Tos)-OH·DCHA is a protected form of D-histidine. The presence of the tert-butoxycarbonyl (Boc) group on the alpha-amino group provides a stable yet readily cleavable protection mechanism. Simultaneously, the tosyl (p-toluenesulfonyl) group is attached to the imidazole ring of histidine. This tosyl modification is crucial as it blocks the reactive nitrogen atom in the imidazole ring, preventing unwanted side reactions during peptide coupling steps. The dicyclohexylammonium (DCHA) salt form further enhances its handling properties and often aids in its purification.
The primary utility of Boc-D-His(Tos)-OH·DCHA lies in its application in solid-phase peptide synthesis (SPPS). Researchers utilize this protected amino acid to accurately incorporate D-histidine residues into peptide sequences. The well-defined protecting groups allow for controlled elongation of the peptide chain, ensuring high yields and purity of the synthesized peptides. This is particularly important when histidine residues are critical for the peptide's biological activity, receptor binding, or catalytic function.
Beyond standard peptide synthesis, Boc-D-His(Tos)-OH·DCHA finds application in creating modified peptides for biochemical assays, studying protein-ligand interactions, and developing peptide-based diagnostic agents. As a trusted supplier of high-quality biochemical reagents, we provide researchers with the reliable Boc-D-His(Tos)-OH·DCHA needed to push the boundaries of scientific discovery. We encourage you to buy this versatile building block to support your critical research objectives.
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to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
