N-(tert-Butoxycarbonyl)-L-glutamine, commonly known as BOC-L-GLN-OH, with CAS number 13726-85-7, is a sophisticated derivative of the amino acid L-glutamine. Its primary function is to serve as a protected amino acid, making it an indispensable tool in various fields of organic synthesis, most notably peptide synthesis and pharmaceutical intermediate production. Understanding its properties, synthesis, and procurement is essential for researchers and procurement managers.

Chemically, BOC-L-GLN-OH possesses a molecular formula of C10H18N2O5 and a molecular weight of approximately 246.26 g/mol. It typically presents as a white to off-white microcrystalline powder, with a melting point range generally between 114-117 °C. This physical state, combined with its solubility in common organic solvents like DMSO and methanol, facilitates its easy integration into standard laboratory and industrial synthetic protocols. The presence of the tert-butoxycarbonyl (Boc) group is key; it acts as a removable protecting group for the alpha-amino nitrogen atom, allowing for controlled reactions elsewhere in the molecule.

The synthesis of BOC-L-GLN-OH commonly involves the reaction of L-glutamine with di-tert-butyl dicarbonate (Boc anhydride) under alkaline conditions. This reaction is a cornerstone for producing protected amino acids and requires careful control of temperature, pH, and reagent addition to achieve high yields and purity. For example, reactions are often carried out in aqueous sodium hydroxide solution, followed by extraction and purification steps to isolate the final product. The efficiency and scalability of this synthesis are critical for ensuring a stable supply of BOC-L-GLN-OH to the market.

When looking to procure BOC-L-GLN-OH, prospective buyers should prioritize purity and reliability. A minimum assay of ≥99.0% is standard for high-grade material, ensuring minimal contamination and optimal performance in sensitive synthetic processes. For those seeking to buy N-(tert-Butoxycarbonyl)-L-glutamine, understanding the nuances of CAS 13726-85-7 price points is important, balancing cost with the assurance of quality and consistent supply from reputable manufacturers and suppliers.

NINGBO INNO PHARMCHEM CO.,LTD. specializes in providing high-quality BOC-L-GLN-OH. As a dedicated pharmaceutical intermediate supplier, we are equipped to meet the demands of both research laboratories and large-scale manufacturing operations. We encourage interested parties to reach out for a quote and explore how our commitment to quality and service can support your synthetic chemistry needs.