In the realm of pharmaceutical synthesis, a deep understanding of a compound's chemical and physical properties is crucial for successful application and reliable sourcing. Methyl 4-carbamoyl-2,6-dimethyl-N-Boc-L-phenylalaninate, bearing the CAS number 623950-05-0, is a critical intermediate in the production of Eluxadoline, a significant drug for treating Irritable Bowel Syndrome with Diarrhea (IBS-D). This article examines the key characteristics of this molecule and why they matter to R&D scientists and procurement specialists.

Molecular Structure and Functional Groups

At its core, CAS 623950-05-0 is a derivative of the amino acid L-phenylalanine. It features several key functional groups: a methyl ester, an N-tert-butoxycarbonyl (Boc) protecting group, and a carbamoyl group attached to the phenyl ring. The Boc group is widely used in peptide synthesis and organic chemistry to temporarily block the amine functionality, allowing for selective reactions elsewhere in the molecule. The carbamoyl group and the specific substitution pattern on the phenyl ring are critical for the subsequent steps in Eluxadoline synthesis. As a manufacturer and supplier, understanding these structural nuances helps us better serve our clients by providing precisely what they need.

Physical and Chemical Characteristics for Application

The physical state and stability of an intermediate directly influence its handling, storage, and reactivity. Methyl 4-carbamoyl-2,6-dimethyl-N-Boc-L-phenylalaninate is typically supplied as a white to off-white powder. This form indicates a certain level of purity and ease of handling. Its molecular weight is approximately 350.41 g/mol, and its chemical formula is C18H26N2O5. While detailed physical properties like boiling point (479.1±45.0 °C at 760 mmHg) and flash point (243.6±28.7 °C) indicate its stability under various conditions, its primary value for pharmaceutical applications lies in its reactivity under specific synthetic transformations. Ensuring minimal moisture content (≤0.5%) is vital for preventing hydrolysis of the ester or degradation of other sensitive groups.

Quality Standards and Sourcing Considerations

For any buyer looking to purchase CAS 623950-05-0, the assay value is a critical indicator of quality. An assay of ≥98.0% signifies a high degree of purity, essential for pharmaceutical synthesis where impurities can lead to side reactions or affect the final API's profile. NINGBO INNO PHARMCHEM CO.,LTD. focuses on sourcing and supplying intermediates that meet these exacting standards. Our commitment as a supplier in China means we can offer this crucial compound with the quality and reliability needed for both R&D and commercial production. When you request a quote, it's important to align your specific purity needs with our product specifications.

Impact on Drug Synthesis

The specific chemical properties of Methyl 4-carbamoyl-2,6-dimethyl-N-Boc-L-phenylalaninate are tailored for its role in Eluxadoline synthesis. The Boc group can be readily removed under acidic conditions, exposing the amine for further coupling reactions. The ester can be hydrolyzed or otherwise transformed as required. These predictable reactions make it an ideal building block for chemists. As a manufacturer and supplier, we understand these requirements and ensure that our product contributes positively to your synthetic route, facilitating efficient Eluxadoline production.