For organic chemists and process developers, a deep understanding of a chemical's properties is fundamental to successful synthesis. H-Glu(OtBu)-OMe·HCl (CAS: 16948-36-0) is one such compound whose specific chemical characteristics make it a valuable building block, particularly in peptide and complex organic molecule synthesis. Knowing these properties helps in making informed decisions when looking to buy or procure this material.

The molecular formula of H-Glu(OtBu)-OMe·HCl is C10H20ClNO4, with a molecular weight of approximately 253.72300. This compound is a derivative of glutamic acid, a naturally occurring amino acid. The key modifications that define its utility are the protective groups and esterification. The presence of the tert-butyl ester on the gamma-carboxyl group (the side chain carboxyl) is a key feature. Tert-butyl esters are commonly employed as protecting groups in organic synthesis because they are stable under neutral and mildly basic conditions but can be efficiently cleaved under acidic conditions. This orthogonality allows for selective manipulation of functional groups within a larger molecule.

Furthermore, the alpha-carboxyl group is present as a methyl ester. Methyl esters, while generally more stable than tert-butyl esters to acidic cleavage, can also be hydrolyzed under specific conditions, offering another avenue for functionalization. The amine group, being protonated as a hydrochloride salt, is typically less reactive and easier to handle, often requiring neutralization before participating in reactions like amide bond formation, which is central to peptide synthesis.

When considering the purchase of H-Glu(OtBu)-OMe·HCl from a chemical manufacturer, understanding its PSA (Polar Surface Area) and LogP values can also be informative for predicting its behavior in different solvent systems or during chromatographic purification. With a PSA of 78.62000 and a LogP of 2.11090, it indicates a moderate polarity and lipophilicity. These figures are helpful for chemists when designing reaction conditions or purification strategies.

For those seeking to buy this compound, it's crucial to source it from reputable suppliers who can provide detailed specifications and ensure its quality. Manufacturers in China offering H-Glu(OtBu)-OMe·HCl (CAS: 16948-36-0) often specialize in producing such chiral building blocks and intermediates. When you inquire about their price or request a sample, ensure they can confirm the purity and the specific esterification and protection status, which are vital for successful organic synthesis. Reliable sourcing is key to ensuring your research or production runs smoothly.