Clomipramine Hydrochloride, identified by its CAS number 17321-77-6, is a chemical compound widely recognized for its pharmacological activity, particularly its potent and selective inhibition of the serotonin (5-HT) reuptake transporter. This characteristic makes it an invaluable tool for researchers in neuroscience, pharmacology, and related fields. Understanding its properties and research applications is key for scientists and procurement specialists looking to source this compound effectively.

Key Properties and Identification

The chemical identity of Clomipramine Hydrochloride is confirmed by its molecular formula C19H23ClN2•HCl and a molecular weight of 351.32. It typically presents as an off-white solid, with specific solubility characteristics in various solvents, such as water (25 mg/mL). For researchers, accurate identification is crucial, and the CAS number 17321-77-6 serves as its unique identifier in databases and scientific literature. Manufacturers often provide purity levels, commonly exceeding 98% by HPLC, ensuring its suitability for rigorous scientific investigation.

Research Applications of Clomipramine Hydrochloride

The primary application of Clomipramine Hydrochloride in research stems from its role as a serotonin reuptake inhibitor. This action allows scientists to:

• Investigate Serotonergic Pathways: Researchers use Clomipramine Hydrochloride to study the intricate mechanisms of the serotonergic system, which is implicated in a wide array of physiological and psychological processes, including mood regulation, sleep, and appetite.
• Model Neurological Disorders: Its established effects on serotonin levels make it a valuable agent in animal models designed to study conditions like depression, obsessive-compulsive disorder (OCD), and anxiety. By observing the effects of Clomipramine Hydrochloride, scientists can gain insights into disease pathology and potential therapeutic targets.
• Evaluate New Drug Candidates: In the development of novel antidepressants and anxiolytics, Clomipramine Hydrochloride often serves as a positive control or a reference compound. This helps in assessing the efficacy and selectivity of newly synthesized molecules.
• Pharmacological Studies: Its binding affinities to various receptors and transporters are well-documented, making it a standard compound for pharmacological profiling and comparative studies within drug discovery programs.

Sourcing and Availability

For those looking to buy Clomipramine Hydrochloride, sourcing from reliable manufacturers and suppliers is essential to ensure product quality and consistency. Companies specializing in fine chemicals and pharmaceutical intermediates, particularly those based in China, are major providers. When you purchase Clomipramine Hydrochloride, always confirm the CAS number, purity, and documentation (like a Certificate of Analysis) to meet your specific research needs. We are a dedicated supplier, committed to providing researchers with high-quality Clomipramine Hydrochloride to advance their scientific endeavors.