In the realm of biochemistry and pharmaceutical development, understanding the nuanced roles of specific molecules is key. D-Isoleucine, identified by CAS number 319-78-8, is a vital component whose properties and applications warrant close examination by professionals in the field. As an essential amino acid, though non-proteinogenic in its D-form, it offers unique benefits and serves as a critical ingredient in numerous research and manufacturing processes.

D-Isoleucine, or (2R,3R)-2-Amino-3-methylpentanoic acid, is characterized by its branched-chain aliphatic side chain. Unlike the more commonly encountered L-Isoleucine, the D-enantiomer is not typically synthesized by the human body and therefore must be obtained through external sources if needed for specific metabolic or research purposes. Its significance often lies in its use as a pharmaceutical intermediate, where its defined stereochemistry is leveraged in the synthesis of complex active pharmaceutical ingredients (APIs).

Key Properties of D-Isoleucine

When considering D-Isoleucine for purchase, understanding its physical and chemical properties is essential:

• Appearance: Typically presented as a white to off-white crystalline powder.
• Purity: High purity, often exceeding 99%, is crucial for its intended applications.
• Solubility: Exhibits some solubility in aqueous acids and water.
• CAS Number: 319-78-8 is the definitive identifier for this specific isomer.

For those looking to buy D-Isoleucine, it is important to ensure that the supplier can provide comprehensive documentation, including a Certificate of Analysis (CoA) detailing these properties and confirming the purity.

Applications Driving Demand for D-Isoleucine

The demand for D-Isoleucine is primarily driven by its utility in:

• Pharmaceutical Intermediate: It serves as a valuable chiral building block in the synthesis of various APIs, contributing to the stereospecificity of the final drug product.
• Biochemical Research: Used in studies investigating metabolic pathways, enzyme functions, and the biological effects of D-amino acids.
• Peptide Synthesis: As a non-canonical amino acid, it can be incorporated into synthetic peptides to modify their properties, such as stability or receptor binding.

Manufacturers and suppliers of D-Isoleucine in China offer competitive pricing and reliable quality, making them attractive partners for global procurement needs. When seeking a supplier, prioritize those with strong quality control and a proven track record.

For R&D professionals and procurement specialists, understanding the precise needs for D-Isoleucine – whether for research or as a key intermediate – will guide the selection of a high-quality product from a dependable manufacturer. Procuring this essential amino acid from trusted sources is fundamental for consistent research outcomes and efficient production.