In the intricate world of pharmaceutical manufacturing, the quality and availability of key intermediates are paramount. One such crucial compound is Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, identified by its CAS number 256504-39-9. This heterocyclic organic compound plays a pivotal role as a building block in the synthesis of various pharmaceuticals, most notably Riociguat, a medication used to treat pulmonary hypertension. For procurement managers and R&D scientists seeking reliable sourcing for this vital chemical, understanding its specifications and the market landscape is essential.

The Chemical Profile and Significance

Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate boasts a molecular formula of C13H14FN3O2 and a molecular weight of 263.27 g/mol. Sourced from reputable manufacturers, it typically presents as an off-white to yellow solid, with a guaranteed purity assay of ≥98.0%. This high level of purity is critical for ensuring the efficacy and safety of the final drug product. Its structure, featuring a fluorobenzyl group attached to a pyrazole ring with an ethyl carboxylate ester, makes it a versatile intermediate for complex organic synthesis pathways.

The primary application driving demand for this compound is its role as an intermediate in the synthesis of Riociguat. Riociguat is a stimulator of soluble guanylate cyclase (sGC) and is used in the treatment of chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary arterial hypertension (PAH). The precise synthesis of Riociguat relies heavily on the consistent quality and availability of intermediates like Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate.

Sourcing Strategies for Pharmaceutical Manufacturers

For companies looking to purchase Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate, identifying dependable suppliers is key. The market offers various manufacturers, with a significant concentration in China. When evaluating suppliers, procurement professionals should look for companies that can demonstrate:

• Consistent product quality: Ensuring the ≥98.0% assay and adherence to specifications.
• Reliable supply chain: Capacity to meet production demands without interruption.
• Competitive pricing: Offering fair market value for the intermediate.
• Regulatory compliance: Adherence to international quality standards.

Many suppliers offer comprehensive documentation, including Certificates of Analysis (CoA) and Material Safety Data Sheets (MSDS), which are vital for internal quality control and regulatory submissions. Exploring options to buy this intermediate in various quantities, from grams for research to kilograms for commercial production, allows for flexible procurement.

Future Outlook and Industry Importance

As the pharmaceutical industry continues to innovate and develop treatments for cardiovascular and pulmonary diseases, the demand for specialized intermediates like Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate is expected to remain strong. For companies operating in this sector, securing a stable supply of this crucial building block is not just about cost-effectiveness but also about ensuring the uninterrupted production of life-saving medications. Partnering with experienced manufacturers and suppliers can provide a significant competitive advantage in this demanding market.

If you are looking to buy Ethyl 5-Amino-1-(2-fluorobenzyl)-1H-pyrazole-3-carboxylate or need a reliable supplier for CAS 256504-39-9 in China, reaching out for a quote is the first step towards securing your supply chain needs.