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The compound's identity is firmly established by its CAS number, 122996-47-8, which serves as a universal reference for its chemical specifications. Its molecular formula, C24H27NO5, and molecular weight of approximately 409.47 g/mol, provide essential details for chemists. The defining characteristic of Fmoc-Hyp(tBu)-OH is the presence of the Fmoc (9-fluorenylmethoxycarbonyl) protecting group on the amine functionality and a tert-butyl ether protecting group on the hydroxyl of the hydroxyproline ring. This dual protection strategy is fundamental to its utility in solid-phase peptide synthesis (SPPS). When researchers choose to buy Fmoc-Hyp(tBu)-OH, they are investing in a reagent that ensures selective deprotection and efficient coupling, leading to higher yields and purer peptide products. Many suppliers, including those based in China, offer this compound, allowing for competitive pricing and accessibility.
The synthesis of Fmoc-Hyp(tBu)-OH typically involves the selective protection of L-hydroxyproline. The tert-butyl protection of the hydroxyl group is crucial because it is stable under the basic conditions used for Fmoc deprotection but can be removed under acidic conditions, often during the final cleavage of the peptide from the resin. This orthogonality in protecting groups is a key principle in efficient peptide synthesis. Understanding these chemical properties is vital for optimizing synthesis protocols. The availability of this reagent from companies like NINGBO INNO PHARMCHEM CO.,LTD. ensures that academic and industrial laboratories have access to the materials needed for cutting-edge research.
The applications of Fmoc-Hyp(tBu)-OH extend to the creation of peptides with modified structures, which can possess enhanced stability against enzymatic degradation or exhibit unique conformational properties. This makes it invaluable in fields ranging from medicinal chemistry and drug discovery to the development of novel biomaterials. The consistent quality and availability of this compound are therefore critical factors for the successful progression of these research endeavors.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
