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Fmoc-Hyp(tBu)-OH, identified by CAS number 122996-47-8, is a specialized derivative of hydroxyproline that has garnered significant attention in the fields of peptide synthesis and medicinal chemistry. As a protected amino acid, its unique structure and properties make it an invaluable building block for complex molecular architectures. Understanding these characteristics is vital for researchers and procurement specialists looking to source this chemical intermediate.
The compound's chemical properties are well-defined: its molecular formula is C24H27NO5, with a molecular weight of approximately 409.475. It typically presents as a white powder, indicating good purity and ease of handling in laboratory settings. Key physical parameters, such as a melting point of 63ºC and a boiling point of 578.6ºC at 760 mmHg, provide further insights into its stability and behavior under various conditions. These specifications are critical for R&D scientists when designing synthesis protocols.
The primary application of Fmoc-Hyp(tBu)-OH lies in its role as a protected amino acid in peptide synthesis, particularly within solid-phase peptide synthesis (SPPS). The Fmoc (9-fluorenylmethyloxycarbonyl) group serves as a base-labile protecting group for the amine function, while the tert-butyl (tBu) ether protects the hydroxyl group on the proline ring. This dual protection strategy allows for controlled, sequential addition of amino acids, enabling the construction of complex peptide chains with high fidelity. Researchers often buy this intermediate to synthesize peptides with specific therapeutic or diagnostic properties.
For procurement managers, sourcing this chemical from reliable manufacturers in China ensures both quality and cost-effectiveness. Reputable suppliers offer Fmoc-Hyp(tBu)-OH with guaranteed purity levels, often exceeding 95%, which is essential for reproducible results in sensitive synthesis processes. When looking to purchase, consider companies that not only provide the product but also offer technical support and custom synthesis services to meet specialized project needs.
NINGBO INNO PHARMCHEM CO.,LTD. stands as a dedicated manufacturer and supplier of high-quality pharmaceutical intermediates like Fmoc-Hyp(tBu)-OH. We are committed to providing the chemical community with the building blocks necessary for groundbreaking research and development. Partner with us to procure this essential compound for your advanced chemical synthesis endeavors.
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