For researchers and procurement specialists in the pharmaceutical and chemical industries, understanding the precise specifications of key intermediates is fundamental to successful projects. Fmoc-Sta-OH (CAS 158257-40-0), a crucial component in peptide synthesis and drug development, requires careful attention to its detailed properties. This article outlines the essential specifications for Fmoc-Sta-OH and their importance for researchers looking to buy this compound.

Core Specifications for Fmoc-Sta-OH

When sourcing Fmoc-Sta-OH, several technical specifications are critical for ensuring its suitability for demanding applications:

• Purity: This is arguably the most important specification. High-purity Fmoc-Sta-OH, typically ≥98% as determined by High-Performance Liquid Chromatography (HPLC), is essential for reproducible and efficient peptide synthesis. Impurities can lead to side reactions, reduced yields, and difficulties in purifying the final peptide product. Researchers often seek suppliers who can provide detailed HPLC chromatograms with their Certificate of Analysis (CoA).
• Appearance: Fmoc-Sta-OH is generally supplied as a white to off-white powder or solid. Any deviation from this description could indicate potential degradation or contamination.
• Molecular Formula and Weight: The molecular formula (C23H27NO5) and molecular weight (approximately 397.46 g/mol) are standard identifiers. These confirm the chemical identity of the product.
• CAS Number: The Chemical Abstracts Service (CAS) Registry Number, 158257-40-0, is a unique identifier ensuring that you are procuring the correct chemical entity.
• Optical Rotation: As a chiral molecule, Fmoc-Sta-OH has a specific optical rotation, often specified as [α]D25. For example, a value like -28 ± 2º (C=1, in DMF) indicates the specific enantiomer being supplied and its optical purity, which is critical for stereoselective synthesis.
• Storage Conditions: Manufacturers typically recommend specific storage conditions, such as storing at -20°C in a tightly sealed container, to maintain stability and prevent degradation. Adhering to these conditions is vital for preserving the quality of the purchased material.

The Significance of Specifications in Application

These specifications directly impact the application of Fmoc-Sta-OH in various research and development contexts:

• Peptide Synthesis: High purity and correct chirality are paramount for efficient peptide bond formation and building complex peptide structures accurately. The Fmoc group’s stability and cleavage characteristics are also vital.
• Drug Development: In medicinal chemistry, the consistent quality of intermediates like Fmoc-Sta-OH directly influences the success of synthesizing novel drug candidates. It aids in developing peptide-based therapeutics with improved stability and efficacy.
• Bioconjugation and Materials Science: For advanced applications, the defined chemical properties ensure predictable reactivity and compatibility with other molecules or substrates.

When you search for an 'Fmoc-Sta-OH manufacturer' or 'Fmoc-Sta-OH supplier,' always prioritize those who provide detailed and verifiable specifications. A reputable supplier, such as NINGBO INNO PHARMCHEM CO.,LTD., will offer comprehensive product data and support, ensuring you obtain the highest quality intermediate for your critical research and development needs.