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Lidocaine Hydrochloride is a fundamental compound in the pharmaceutical armamentarium, primarily recognized for its efficacy as a local anesthetic and its role as an antiarrhythmic agent. Understanding its pharmacological properties is key to appreciating its broad utility in healthcare. NINGBO INNO PHARMCHEM CO.,LTD. supplies high-quality Lidocaine Hydrochloride powder, enabling its application in numerous critical medical contexts.
Mechanism of Action
As a local anesthetic, Lidocaine Hydrochloride acts by reversibly blocking voltage-gated sodium channels in the neuronal cell membrane. This blockade prevents the influx of sodium ions necessary for depolarization, thereby inhibiting the initiation and propagation of nerve impulses. Consequently, it leads to a temporary loss of sensation in the area of administration. Its class IB antiarrhythmic action involves a similar mechanism, affecting sodium channels in cardiac muscle cells to stabilize the heart rhythm, particularly in cases of ventricular arrhythmias.
Pharmacokinetics and Metabolism
Lidocaine Hydrochloride is rapidly absorbed following parenteral administration. Its absorption rate is influenced by factors such as the route of administration and the presence of vasoconstrictors like epinephrine, which prolong its local effects by reducing systemic absorption. The drug is extensively metabolized in the liver, primarily through N-de-ethylation, forming metabolites like monoethylglycinexylidide (MEGX) and glycinexylidide, which retain some pharmacological activity. The liver's metabolic capacity significantly influences the drug's elimination half-life, which is typically around 1.5 to 2 hours in healthy individuals but can be prolonged in cases of liver dysfunction.
Clinical Applications and Dosage Considerations
The clinical uses of Lidocaine Hydrochloride are diverse:
Dosage varies significantly depending on the intended use, route of administration, and patient factors. When considering the purchase of Lidocaine Hydrochloride powder, it's crucial to source from manufacturers who can provide detailed specifications and quality certifications to ensure appropriate use and patient safety.
Sourcing High-Quality Lidocaine Hydrochloride
NINGBO INNO PHARMCHEM CO.,LTD. emphasizes the importance of sourcing pharmaceutical-grade Lidocaine Hydrochloride. Our commitment to quality ensures that the powder meets stringent purity requirements and pharmacopoeial standards, making it suitable for sensitive medical applications. Reliable access to this compound is critical for healthcare providers and pharmaceutical manufacturers alike.
Conclusion
Lidocaine Hydrochloride remains an indispensable agent in both anesthesia and cardiology. Its well-understood pharmacological profile, combined with careful sourcing from trusted suppliers like NINGBO INNO PHARMCHEM CO.,LTD., ensures its continued effective and safe use in patient care.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
