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In the rapidly evolving field of targeted cancer therapy, Antibody-Drug Conjugates (ADCs) have emerged as a powerful modality. Central to the efficacy of ADCs is the cytotoxic payload – a highly potent molecule designed to kill cancer cells. One such critical payload is Mertansine, scientifically known as N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine, identified by CAS number 139504-50-0. Understanding its properties and applications is essential for researchers and procurement specialists in the pharmaceutical sector.
Mertansine is a derivative of maytansine, a natural antimitotic agent derived from plants. Its potency stems from its ability to bind to tubulin, a protein crucial for microtubule formation within cells. By inhibiting microtubule polymerization, Mertansine effectively halts cell division, leading to programmed cell death (apoptosis), particularly in rapidly proliferating cancer cells. This targeted mechanism makes it an ideal candidate for use in ADCs, where it is conjugated to a monoclonal antibody specific to cancer cell surface antigens.
From a chemical perspective, Mertansine has a complex molecular structure with the formula C35H48ClN3O10S and a molecular weight of approximately 738.29 g/mol. It typically presents as a white or light yellow crystalline powder, with a melting point range of 190-192℃ (with decomposition). As a supplier of this compound, ensuring its high purity, typically 98%, is paramount. This ensures its optimal performance when conjugated and administered as part of an ADC, minimizing off-target effects.
The demand for reliable sources of high-purity Mertansine continues to grow as ADC research and development accelerates. For companies seeking to buy this critical pharmaceutical intermediate, partnering with experienced manufacturers and suppliers is key. We offer N2'-deacetyl-N2'-(3-Mercapto-1-oxopropyl)-Maytansine, ensuring quality and consistency for your research and development needs. If you are exploring its use in your next ADC project, we encourage you to inquire about our product specifications, pricing, and supply capabilities. Our commitment is to support your innovation in oncology drug development.
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