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NINGBO INNO PHARMCHEM CO.,LTD. is dedicated to providing comprehensive insights into the materials we supply, and Microcrystalline Cellulose (MCC) is no exception. The performance of MCC in pharmaceutical formulations, particularly in tablet manufacturing, is highly dependent on its specific grade. Each grade possesses unique characteristics in terms of particle size, density, and moisture content, which significantly impact its suitability for different processes like direct compression and wet granulation. Understanding these nuances is key to achieving optimal tablet quality and manufacturing efficiency.
The core of MCC's utility lies in its ability to act as a binder and filler. Its inherent compressibility allows for the creation of robust tablets. However, the specific grade of MCC chosen can dramatically influence the outcome. For example, MCC grades with finer particle sizes, like MCC 101, tend to have higher surface areas, which can be beneficial in wet granulation for promoting uniform wetting and binding. Conversely, grades with larger particle sizes and improved flowability, such as MCC 102, are often favored for direct compression, where smooth powder flow is critical for consistent tablet weight and hardness. The choice between these grades is a critical decision in tablet manufacturing.
Microcrystalline cellulose applications are diverse, and the selection of the appropriate grade is paramount. For direct compression, MCC grades that offer excellent flow and low lubricant sensitivity are preferred. These grades ensure that the powder blends move smoothly through the tablet press and form compact tablets without sticking. In wet granulation, MCC's wicking action helps to distribute the granulating fluid evenly, leading to more uniform granules. The ability to choose MCC based on specific processing needs highlights the importance of detailed microcrystalline cellulose properties knowledge. NINGBO INNO PHARMCHEM CO.,LTD. offers a selection of MCC grades, each characterized to support various formulation strategies.
The microcrystalline cellulose as binder function is a primary reason for its widespread use. It facilitates the formation of strong inter-particulate bonds, ensuring tablet integrity. However, different grades may exhibit slightly different binding efficiencies. Furthermore, the impact of MCC on tablet disintegration and dissolution rates must also be considered. Some grades may promote faster disintegration, which is desirable for immediate-release formulations. Our commitment at NINGBO INNO PHARMCHEM CO.,LTD. is to provide our clients with the necessary information and high-quality MCC to navigate these choices effectively. Whether you are looking to buy microcrystalline cellulose for a new product or optimize an existing one, understanding grade selection is fundamental to success in pharmaceutical excipient science.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
