Nicotinamide N-oxide, identified by CAS number 1986-81-8, is a compound of significant interest within the chemical and pharmaceutical research communities. As a metabolite of nicotinamide, a form of Vitamin B3, it plays a crucial role in various biological processes. Understanding its properties and applications is key for researchers looking to advance their work in areas such as metabolic studies and drug discovery.

One of the primary functions of Nicotinamide N-oxide is its involvement in the metabolism of nicotinamide. Nicotinamide itself is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for numerous biochemical reactions, including cellular respiration and DNA repair. Nicotinamide N-oxide is formed through enzymatic oxidation of nicotinamide, primarily by cytochrome P450 enzymes. Studying this metabolic pathway can provide insights into how the body processes essential nutrients and how imbalances might contribute to certain health conditions.

Beyond its role as a metabolite, Nicotinamide N-oxide has gained prominence as a potent and selective antagonist of the CXCR2 receptor. CXCR2 is a key chemokine receptor involved in inflammatory responses, particularly in the recruitment of neutrophils. This property makes Nicotinamide N-oxide a valuable tool for researchers investigating inflammatory diseases, autoimmune disorders, and other conditions where neutrophil activity plays a central role. The ability to selectively block CXCR2 signaling opens avenues for developing new therapeutic strategies.

For procurement, identifying reliable sources for high-purity Nicotinamide N-oxide is paramount. Researchers often seek out reputable manufacturers and suppliers who can guarantee consistent quality and competitive pricing. Companies specializing in pharmaceutical intermediates and fine chemicals, particularly those operating as a chemical manufacturer in China, often provide accessible options for obtaining this compound. When looking to buy Nicotinamide N-oxide, it is advisable to consult product specifications, purity levels (often expressed as a percentage, e.g., 97%+), and CAS numbers to ensure suitability for your specific research needs. Requesting a quote is a standard step to ascertain the current market price and availability.

The chemical properties of Nicotinamide N-oxide, such as its molecular formula (C6H6N2O2) and melting point (around 291-293 °C with decomposition), are critical data points for formulation chemists and researchers. These specifications, coupled with its known applications, solidify its importance as a research chemical. Whether for detailed metabolic pathway analysis or for exploring novel anti-inflammatory therapies, Nicotinamide N-oxide remains a compound of substantial scientific value. When considering purchase, prioritize suppliers with a strong track record and transparent product information.