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Understanding ODM-201: A Next-Gen AR Inhibitor for Prostate Cancer

Prostate cancer remains a significant health concern for men worldwide. While androgen deprivation therapy (ADT) is a cornerstone treatment, many patients eventually develop castration-resistant prostate cancer (CRPC). This progression is often driven by various resistance mechanisms, including mutations and overexpression of the androgen receptor (AR). As a leading pharmaceutical intermediate manufacturer and supplier in China, we are committed to providing advanced compounds like ODM-201, which represent the forefront of CRPC treatment research.

ODM-201 (CAS: 1297538-32-9) is a novel, next-generation AR inhibitor that has garnered significant attention due to its impressive preclinical and early clinical data. Unlike earlier generations of AR antagonists, ODM-201 exhibits a superior binding affinity to the AR and critically, it functions as a potent antagonist against key AR mutations, such as F876L, which are known to confer resistance to drugs like enzalutamide and ARN-509. This ability to overcome common resistance mechanisms makes ODM-201 a highly promising candidate for patients whose disease has progressed on standard therapies.

Furthermore, ODM-201 demonstrates remarkable efficacy in preclinical models of CRPC. Studies have shown that it suppresses tumor growth more effectively than other tested AR inhibitors. A key advantage highlighted in research is its negligible brain penetrance. This characteristic is crucial as it significantly reduces the risk of neurological side effects, such as seizures, which have been observed with some other AR-targeted therapies. This improved safety profile contributes to better patient tolerability and quality of life.

For research scientists and procurement managers in the pharmaceutical industry, understanding the role of compounds like ODM-201 is vital. As a dedicated manufacturer and supplier based in China, we offer high-purity ODM-201 to support your drug discovery and development pipelines. We understand the importance of supply chain reliability and competitive pricing for advanced intermediates. If you are looking to buy ODM-201 or seeking a dependable supplier for this critical compound, we are here to meet your needs. Contact us today to inquire about ODM-201 price and availability, and to learn how our commitment to quality can benefit your projects.

Manufacturing Facilities

NINGBO INNO PHARMCHEM CO.,LTD. was established in 2007. It is committed to the R&D, production and sales of raw materials, pharmaceutical intermediates and fine chemicals. We striving to create a high-efficiency and high-quality integrated chemical service platform to better serve domestic and foreign customers.

Professional Export Experience

to Global Customers

WHY CHOSE US?

1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;

2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;

3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).

FAQ

  • A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.

  • A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.

  • A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.

CONTACT US
Should you need to contact us; you may call during regular business hours, Monday through Friday, 8am – 6 pm.
NINGBO INNO PHARMCHEM CO.,LTD.
Address: No.163 Ruiqing Rd.,Ningbo 315000 China
Phone: 86-574-87319282
Fax: 86-574-27912196
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