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In the complex world of pharmaceutical synthesis, certain chemical intermediates play pivotal roles, enabling the creation of highly effective therapeutic agents. Omeprazole Sulfide, identified by CAS number 73590-85-9, is one such compound. As a key intermediate, it is indispensable in the manufacturing process of globally recognized gastric proton pump inhibitors (PPIs) like Omeprazole and Esomeprazole. For researchers and procurement specialists in the pharmaceutical industry, a thorough understanding of this chemical's properties and applications is crucial.
Omeprazole Sulfide, also known by synonyms such as Ufiprazole or Omeprazole Sulfide, possesses a distinct molecular structure (C17H19N3O2S) with a molecular weight of 329.42 g/mol. Typically appearing as a white powder, it exhibits a melting point in the range of 115-119°C. These characteristics are vital for its identification and quality assessment. Manufacturers strive to achieve a minimum purity of 97% to ensure its efficacy in subsequent synthetic steps.
The primary application of Omeprazole Sulfide lies in its role as a precursor in the multi-step synthesis of Omeprazole and Esomeprazole. These drugs are cornerstones in treating acid-related disorders, including peptic ulcers and gastroesophageal reflux disease (GERD). The sulfur linkage within the Omeprazole Sulfide molecule is a key functional group that undergoes specific chemical transformations to form the active drug substance.
Beyond its direct role in synthesis, Omeprazole Sulfide is also recognized as Omeprazole Impurity C. This dual nature means it is not only purchased as a raw material but also monitored as a potential degradation product during drug stability testing. Therefore, having a reliable source for high-purity Omeprazole Sulfide is essential for both manufacturing and quality control departments.
Sourcing this critical intermediate often leads pharmaceutical companies to inquire about manufacturers, especially those located in regions known for chemical production, such as China. When looking to buy Omeprazole Sulfide, buyers should prioritize suppliers who can guarantee consistent quality, provide comprehensive technical data, and offer competitive pricing. Factors like storage conditions (-20°C freezer recommended) and handling advice also contribute to maintaining product integrity.
In summary, Omeprazole Sulfide is a fundamentally important pharmaceutical intermediate. Its role in the synthesis of essential PPIs underscores its significance in modern medicine. By understanding its chemical properties, applications, and sourcing considerations, pharmaceutical professionals can ensure the efficient and reliable production of vital treatments.
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