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Oxidative stress is a fundamental process implicated in aging and a wide array of diseases, particularly neurodegenerative conditions like Alzheimer's disease. The brain, with its high metabolic rate and susceptibility to lipid peroxidation, is particularly vulnerable. Fortunately, nature often provides powerful antioxidants, and Peganum harmala extract, containing the alkaloid harmine, is proving to be a significant player in this natural defense system.
Research has highlighted the potent antioxidant capabilities of Peganum harmala extract. In preclinical studies, it has been observed to mitigate the damaging effects of oxidative stress in the brain. This protection is achieved by influencing key antioxidant pathways. For instance, the extract has been shown to boost the levels of glutathione (GSH) and enhance the activity of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway. Nrf2 is a master regulator of the cellular antioxidant response, promoting the production of various protective enzymes and proteins.
By activating Nrf2, Peganum harmala extract helps to neutralize harmful reactive oxygen species (ROS) and reduce the accumulation of malondialdehyde (MDA), a marker of lipid peroxidation. This reduction in oxidative damage is crucial for preserving neuronal integrity and function. In the context of neurodegenerative diseases, where oxidative stress is a significant contributor to pathology, these effects are particularly beneficial.
The connection between oxidative stress and other disease mechanisms, such as insulin resistance, is also noteworthy. Oxidative stress can disrupt insulin signaling in the brain, exacerbating conditions like Alzheimer's disease. Peganum harmala extract's dual action—combating oxidative stress while simultaneously improving insulin signaling—suggests a synergistic approach to neuroprotection. This combined effect offers a more comprehensive strategy for maintaining brain health.
For the pharmaceutical and nutraceutical industries, understanding these antioxidant mechanisms provides a strong rationale for incorporating Peganum harmala extract into products aimed at supporting brain health. As awareness grows regarding the role of oxidative stress in cognitive decline and aging, natural antioxidants like harmine become increasingly valuable. Further research into the specific mechanisms and optimal applications of Peganum harmala extract in managing oxidative stress will undoubtedly pave the way for innovative health solutions.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
