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Prodrug technology represents a sophisticated approach in pharmaceutical development, where a drug is administered in an inactive or less active form that is metabolized into its active form within the body. This strategy is often employed to overcome challenges such as poor oral bioavailability, chemical instability, or adverse side effects. A prime example of this innovative technology is Valganciclovir Hydrochloride, a prodrug of the antiviral agent ganciclovir.
The design of Valganciclovir prodrug mechanism significantly enhances the oral absorption of ganciclovir. Ganciclovir itself has relatively low oral bioavailability, necessitating intravenous administration for effective treatment. By attaching an L-valyl ester to ganciclovir, Valganciclovir is created. This ester group is efficiently cleaved by esterases in the intestine and liver, releasing active ganciclovir into the bloodstream. This conversion mechanism allows for an oral dosage form, greatly improving convenience and patient adherence for conditions like Valganciclovir for CMV retinitis treatment and Valganciclovir organ transplant prophylaxis.
This enhancement in ganciclovir bioavailability through its prodrug form translates directly to better therapeutic outcomes and reduced healthcare burden. Patients can manage their conditions at home, avoiding frequent hospital visits for intravenous infusions. The success of Valganciclovir underscores the potential of prodrug strategies to transform drug delivery and patient quality of life. NINGBO INNO PHARMCHEM CO.,LTD. plays a vital role in this by providing high-quality Valganciclovir Hydrochloride (CAS 175865-59-5) to pharmaceutical manufacturers globally.
For those in drug development and sourcing, understanding the intricacies of prodrugs like Valganciclovir is essential. Reputable suppliers like NINGBO INNO PHARMCHEM CO.,LTD. are instrumental in ensuring the consistent availability of this critical compound. If you are looking to buy Valganciclovir HCl bulk or are seeking a reliable Valganciclovir HCl manufacturer, partnering with a company that prioritizes purity and efficacy ensures that your pharmaceutical products will meet the highest standards, benefiting patients through improved drug delivery systems enabled by smart prodrug design.
Manufacturing Facilities
Professional Export Experience
to Global Customers
1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
