For scientists and researchers in the chemical and pharmaceutical industries, a deep understanding of the physical and chemical properties of key intermediates is fundamental to successful synthesis and application. 3-Amino-5-fluoropyridine (CAS: 210169-05-4) is one such compound, whose characteristics dictate its reactivity, stability, and suitability for various advanced applications, from drug development to material science.

Key Physical Characteristics

Appearance: Typically described as white to off-white solids, the visual appearance of 3-Amino-5-fluoropyridine is an initial indicator of its purity. Variations in color might suggest the presence of impurities, making a consistently white or off-white appearance desirable for high-purity grades.

Melting Point: The reported melting point range for 3-Amino-5-fluoropyridine is generally around 86°C (with some sources indicating 85-89°C). This property is crucial for determining its solid-state behavior and handling requirements. It also serves as a key parameter for identity and purity assessment.

Boiling Point: With a boiling point of approximately 217.1°C at 760 mmHg (some sources cite 232.7°C), this compound is relatively stable under standard atmospheric conditions but will vaporize at elevated temperatures. Understanding its boiling point is important for distillation or high-temperature reaction planning.

Flash Point: The flash point, around 85.1°C, indicates the temperature at which it can ignite in the presence of an ignition source. This is a critical safety parameter for handling, storage, and processing, highlighting the need for appropriate fire prevention measures.

Density and Refractive Index: A density of approximately 1.3 g/cm³ and a refractive index of 1.554 provide further physical data points for identification and characterization.

Chemical Reactivity and Stability

The chemical nature of 3-Amino-5-fluoropyridine is defined by its functional groups. The pyridine ring provides aromatic stability, while the amino group (-NH2) is nucleophilic and can participate in a wide array of reactions, including acylation, alkylation, and coupling reactions. The fluorine atom, being highly electronegative, influences the electron distribution within the molecule, affecting its reactivity and potentially enhancing the stability or lipophilicity of derived compounds. This makes it an excellent scaffold for creating molecules with specific biological activities, as utilized by pharmaceutical and agrochemical researchers.

Sourcing High-Quality Material

For R&D professionals, obtaining 3-Amino-5-fluoropyridine with guaranteed purity and accurate property data is essential. NINGBO INNO PHARMCHEM CO.,LTD., as a dedicated manufacturer and supplier, provides this vital intermediate with comprehensive specifications. By trusting a reliable China-based supplier, researchers can ensure they are working with materials that meet exacting scientific standards, facilitating successful experimental outcomes and accelerating discovery.