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In the realm of medical diagnostics, the quality of chemical intermediates directly impacts the performance of life-saving contrast agents. 5-Amino-2,4,6-triiodoisophthalic acid, with the CAS number 35453-19-1, is a key intermediate whose properties are critical for its application in producing advanced X-ray contrast media. For pharmaceutical researchers and procurement specialists, a thorough understanding of this compound's characteristics is vital when considering purchase from a chemical supplier.
Key Physical and Chemical Properties
The appearance of 5-Amino-2,4,6-triiodoisophthalic acid is typically described as a light yellow or off-white powder. This physical characteristic is a primary indicator during visual inspection of the material. Its molecular formula is C8H4I3NO4, and it has a molecular weight of approximately 558.84 g/mol. The compound exhibits a relatively high melting point, generally in the range of 265-270 °C, which signifies its solid state and thermal stability under standard conditions.
Purity and Specifications: A Critical Factor for Buyers
The efficacy of contrast agents like Iohexol, Ioversol, and Iopamidol is directly linked to the purity of their precursors. For 5-Amino-2,4,6-triiodoisophthalic acid, industry standards and factory specifications often require a purity of ≥98.5% as determined by HPLC. This high level of purity ensures that subsequent reactions proceed cleanly, minimizing unwanted byproducts and ensuring the final contrast agent meets stringent pharmaceutical regulatory requirements. Buyers should always check the CoA from their supplier to confirm these critical specifications. Additional parameters such as loss on drying (typically ≤1.0%) and residue on ignition (≤0.1%) further attest to the material’s quality.
Applications in Medical Imaging and Beyond
The primary application of 5-Amino-2,4,6-triiodoisophthalic acid is as a crucial intermediate in the synthesis of nonionic iodinated X-ray contrast agents. These agents are essential for medical imaging procedures, allowing for clearer visualization of anatomical structures and pathologies. Its role in Iohexol, Ioversol, and Iopamidol synthesis makes it a high-demand product in the pharmaceutical industry. Researchers also explore its potential in other areas, such as in the development of novel radiopharmaceuticals or specialized materials, leveraging its unique iodine-rich structure.
Sourcing Strategy for Procurement Managers
When looking to buy 5-Amino-2,4,6-triiodoisophthalic acid, procurement managers should:
By understanding and prioritizing these properties and sourcing considerations, R&D scientists and procurement teams can secure the high-quality 5-Amino-2,4,6-triiodoisophthalic acid necessary for developing effective and safe medical imaging solutions. It’s about more than just purchasing a chemical; it’s about ensuring the reliability and performance of critical diagnostic tools.
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