2-(4-Bromophenyl)pyridine (CAS: 63996-36-1) is a heterocyclic organic compound that serves as a crucial intermediate in various chemical synthesis processes. Its unique structure, featuring a pyridine ring linked to a brominated phenyl ring, endows it with specific reactivity and properties that are highly valued in both academic research and industrial applications, particularly within the pharmaceutical sector.

Physical and Chemical Characteristics

This compound typically presents as a white powder, a physical form that facilitates handling and integration into synthetic procedures. Its melting point, recorded in the range of 61-65℃, is a key indicator of its purity and crystalline structure. The molecular formula is C11H8BrN, with a molecular weight of approximately 234.09 g/mol. Ensuring a high purity level, often specified as 97% minimum by suppliers, is critical for researchers aiming for predictable and reproducible outcomes in their experiments. Reliable chemical suppliers, often manufacturers in China, can provide this material with guaranteed specifications, making it easier for scientists to buy consistent quality.

Reactivity and Synthetic Utility

The chemical reactivity of 2-(4-Bromophenyl)pyridine stems from its distinct functional groups. The bromine atom on the phenyl ring is highly susceptible to various palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling, enabling the formation of new carbon-carbon bonds. This makes it an excellent precursor for creating diverse molecular scaffolds relevant to drug discovery. The pyridine nitrogen atom contributes to the compound's basicity and can coordinate with metal catalysts, further expanding its synthetic utility. Researchers often use it as a building block in the construction of complex heterocyclic systems.

Applications in Research and Industry

The primary application of 2-(4-Bromophenyl)pyridine lies in its role as a pharmaceutical intermediate. It is used in the synthesis of a wide array of biologically active molecules and potential drug candidates. Beyond pharmaceuticals, its structure also lends itself to applications in materials science, potentially as a component in organic light-emitting diodes (OLEDs) or other electronic materials where tailored aromatic systems are required. For procurement managers, identifying a reliable manufacturer that can supply this intermediate consistently and at a reasonable price is a key objective.

In summary, 2-(4-Bromophenyl)pyridine is a versatile and important chemical intermediate. Its well-defined physical and chemical properties, combined with its reactivity in key synthetic transformations, make it a sought-after compound. Sourcing from reputable suppliers who offer high purity and reliable availability, such as specialized chemical manufacturers, is crucial for leveraging its full potential in research and development.