For professionals in the pharmaceutical and fine chemical industries, a deep understanding of key intermediates is fundamental to successful synthesis and product development. (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one, identified by its CAS number 132127-34-5, is one such critical compound, renowned for its role in the production of vital anticancer medications. This article aims to provide a comprehensive overview of its properties, applications, and the importance of sourcing from reliable manufacturers.

Chemical and Physical Profile of a Vital Intermediate

The molecule (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one (C9H9NO2, Molecular Weight: 163.17) presents a specific chiral configuration that is paramount for its function. Typically appearing as a white solid, its physical characteristics, such as a melting point of 187-188°C, indicate a stable compound under standard conditions. Its density is noted at 1.308, and it possesses a refractive index of 1.612, which are important parameters for quality control and handling. Stability under normal temperatures and pressures is a key feature, though recommended storage is often under refrigeration to maintain optimal quality. When seeking to buy this compound, attention to these physical and chemical properties ensures that you are acquiring a material suitable for your intended applications.

The Backbone of Paclitaxel and Docetaxel Synthesis

The primary utility of (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one lies in its role as a crucial intermediate for synthesizing Paclitaxel and its analog, Docetaxel. These drugs are indispensable in modern oncology, used to treat a broad spectrum of cancers. The intermediate's specific chirality is essential for constructing the complex molecular architecture of these drugs, directly influencing their therapeutic efficacy. Manufacturers producing these life-saving agents depend on a consistent supply of this high-purity intermediate. For researchers and production managers, identifying a dependable manufacturer in China, such as NINGBO INNO PHARMCHEM CO.,LTD., is key to securing this vital component.

Quality Assurance and Sourcing Strategies

Sourcing high-quality (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one requires a focus on purity levels, often exceeding 98% (HPLC). Reputable suppliers provide detailed Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS) to ensure compliance and safe handling. When looking to purchase this intermediate, consider manufacturers who can guarantee batch-to-batch consistency and offer competitive pricing, especially for bulk orders. NINGBO INNO PHARMCHEM CO.,LTD. offers comprehensive quality management and a reliable supply chain, making us a preferred partner for pharmaceutical companies worldwide. Our commitment is to provide products that meet the highest industry standards.

Potential Beyond Current Applications

While its current applications are predominantly in the synthesis of established anticancer drugs, the unique beta-lactam scaffold of (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one suggests potential for broader uses in organic synthesis and medicinal chemistry. Its inherent reactivity makes it an attractive starting material for developing novel compounds, including potential new antibiotics or therapeutic agents targeting different biological pathways. Researchers exploring new chemical entities may find this intermediate to be a valuable addition to their synthetic toolkit.

For any organization seeking to procure (3R,4S)-3-Hydroxy-4-phenylazetidin-2-one, partnering with a trusted manufacturer like NINGBO INNO PHARMCHEM CO.,LTD. ensures access to a high-quality, consistent, and competitively priced intermediate, vital for both current pharmaceutical production and future innovation.