Chemical intermediates are the unsung heroes of synthesis, bridging the gap between raw materials and complex final products. For the pharmaceutical industry, compounds like Boc-Phe(3,5-DiF)-OH (CAS 205445-52-9) are invaluable. This article explores the key characteristics of this compound and its importance in various scientific applications, offering insights for procurement professionals and researchers looking to buy.

Chemical Profile of Boc-Phe(3,5-DiF)-OH

Boc-Phe(3,5-DiF)-OH, also known as N-Boc-3,5-difluoro-L-phenylalanine, is characterized by its molecular formula C14H17F2NO4 and a molecular weight of approximately 301.29 g/mol. A crucial aspect for its use as a pharmaceutical intermediate is its physical form and purity. Typically, it presents as a white solid with a melting point around 115°C. The 'Boc' group (tert-butoxycarbonyl) serves as a common protecting group for the amine function in amino acids, facilitating controlled reactions during peptide synthesis or other complex organic transformations.

The '3,5-difluoro' substitution on the phenylalanine ring is a significant feature. This fluorination can influence the compound's electron density, lipophilicity, and susceptibility to metabolic breakdown, making it a desirable building block for designing molecules with specific biological activities and improved pharmacokinetic properties. Researchers looking to purchase this intermediate will often seek it for these very characteristics.

Key Applications and Market Availability

The primary application for Boc-Phe(3,5-DiF)-OH is as a pharmaceutical intermediate. It is widely utilized in:

• Peptide Chemistry: As a protected amino acid, it's a standard reagent in solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis for creating peptides with specific modifications or enhanced stability.
• Drug Discovery: Its unique structure makes it valuable for constructing novel drug candidates, particularly in areas where metabolic stability or altered binding interactions are sought.
• Organic Synthesis: Beyond peptides, it can serve as a versatile chiral building block in broader organic synthesis projects.

For those in the market to buy Boc-Phe(3,5-DiF)-OH, sourcing from reliable manufacturers and suppliers is paramount. Companies seeking this intermediate should look for clear specifications, consistent quality, and dependable delivery. Purchasing from established chemical suppliers, especially those specializing in pharmaceutical intermediates and located in key manufacturing regions like China, can ensure access to high-purity material at competitive prices. When you decide to buy, always inquire about availability and request a quote to secure your supply needs.