For chemists and procurement specialists involved in the synthesis of complex organic molecules, a thorough understanding of chemical intermediates is essential. 5-Chloro-2-hydroxypyridine (CAS 4214-79-3) is one such compound, widely recognized for its utility in pharmaceuticals and agrochemicals. This article aims to provide a detailed overview of its physical and chemical properties, specifications, and storage requirements, as understood by a dedicated manufacturer and supplier.

Key Physical Characteristics

The typical appearance of 5-Chloro-2-hydroxypyridine, as supplied by manufacturers like NINGBO INNO PHARMCHEM CO.,LTD., is an off-white to slight yellow solid. This physical form is consistent across most reputable suppliers and is a good initial indicator of product quality. Its molecular formula is C5H4ClNO, with a molecular weight of approximately 129.54 g/mol. These fundamental properties are crucial for stoichiometric calculations in various synthesis processes.

Critical Chemical Specifications for Synthesis

The most important specification for any chemical intermediate is its purity, often expressed as 'Assay'. For 5-Chloro-2-hydroxypyridine, a high assay of ≥98.0% is typically required to ensure efficient and clean reactions, minimizing the formation of unwanted by-products. This high purity is essential whether you are using it for pharmaceutical synthesis or in the production of sophisticated agrochemicals. Another key indicator is the melting point, which for this compound generally falls within the range of 162-164°C (lit.). Deviations from this range can sometimes indicate impurities or variations in crystalline structure. The ash content, usually specified as ≤0.5%, and heavy metals content (≤10ppm) are also critical parameters, especially for applications in regulated industries like pharmaceuticals.

Understanding Physical and Chemical Properties

While the exact values can vary slightly depending on the source and measurement method, some notable physical and chemical properties include a density of approximately 1.4±0.1 g/cm³ and a boiling point of around 311.0°C at 760 mmHg. The flash point, a measure of flammability, is around 141.9±22.3°C. These properties provide valuable insights for safe handling, storage, and process design when working with 5-Chloro-2-hydroxypyridine. For those looking to buy this compound, understanding these specifications will help in evaluating different suppliers.

Proper Storage and Handling Recommendations

To maintain the integrity and purity of 5-Chloro-2-hydroxypyridine, proper storage is vital. It is recommended to store the material in a cool, well-ventilated place, away from incompatible substances. Keeping the container tightly closed helps prevent moisture absorption and degradation. Manufacturers often package this chemical in 25 kg drums, but custom packaging can be arranged according to specific customer requirements for your purchase.

By familiarizing yourself with these properties and specifications, you can make informed decisions when sourcing 5-Chloro-2-hydroxypyridine, ensuring you acquire a product that meets your high standards for chemical synthesis and manufacturing.