In the fast-paced world of chemical synthesis and pharmaceutical research, understanding the intrinsic properties of key compounds is fundamental to successful experimental design and application. RAD140, also known by its synonym Testolone, with CAS number 1182367-47-0, is a nonsteroidal selective androgen receptor modulator (SARM) that has gained considerable traction in scientific research due to its distinct chemical characteristics and versatile research applications. This article provides an overview of RAD140's chemical properties, its solubility, and its primary uses in scientific studies.

RAD140 is characterized by its molecular formula C20H16ClN5O2 and a molecular weight of approximately 393.83 g/mol. It typically presents as a white crystalline solid. Its chemical structure features a benzonitrile core with a complex side chain containing an oxadiazole ring and a chiral propylamino group, which confers its specific binding affinity to the androgen receptor. The presence of a chlorine atom and a nitrile group on the benzonitrile ring are key structural elements influencing its pharmacological activity and interactions.

For researchers planning experiments, understanding the solubility of RAD140 is critical for preparing accurate stock solutions and formulations. RAD140 exhibits good solubility in polar organic solvents. It is highly soluble in DMSO (Dimethyl sulfoxide), typically exceeding 100 mg/mL (253.92 mM). It is also soluble in ethanol, though to a lesser extent (approximately 2 mg/mL). Solubility in other solvents like chloroform is described as slight. For aqueous solutions, it is sparingly soluble, but can be achieved by first dissolving in ethanol and then diluting with an aqueous buffer, yielding concentrations around 0.25 mg/mL in a 1:3 ethanol:PBS (pH 7.2) solution. Researchers looking to buy RAD140 should consider these solubility parameters for their experimental design.

The primary research application for RAD140 revolves around its function as a selective androgen receptor modulator (SARM). Its high affinity (Ki = 7 nM) for the androgen receptor makes it an excellent tool for studying AR signaling pathways. Studies have demonstrated its tissue-selective anabolic effects on muscle and bone, making it a compound of interest for research into muscle wasting conditions and osteoporosis. Furthermore, its application in oncology research, particularly in the study of AR/ER+ breast cancer models, highlights its therapeutic potential. It's also investigated for neuroprotective properties, suggesting broader applications in neurological research.

When sourcing RAD140 for research purposes, it is imperative to obtain it from a reputable manufacturer or supplier. Ensuring the CAS number (1182367-47-0) and molecular formula are correctly identified, along with verified purity (e.g., >95% or >98% by HPLC), guarantees the integrity of your research. Proper storage, typically at -20°C, is essential to maintain the compound's stability over time. Researchers can readily purchase RAD140 from specialized chemical suppliers who prioritize quality and provide comprehensive product information.

In summary, RAD140 (Testolone) is a sophisticated research chemical with well-defined chemical properties that facilitate its use in a variety of scientific investigations. Its solubility profile and AR binding affinity make it an invaluable tool for studying androgen receptor modulation, muscle physiology, cancer biology, and neuroscience. Accessing high-quality RAD140 from trusted suppliers is key for researchers aiming to achieve accurate and impactful results.