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For chemists and researchers in the pharmaceutical and fine chemical industries, a deep understanding of the compounds they work with is fundamental. 3-Bromo-2-hydroxypyridine (CAS 13466-43-8) is a prime example of an intermediate where detailed knowledge of its synthesis and properties can significantly enhance its effective utilization. This article provides an overview of its characteristics and manufacturing considerations.
The synthesis of 3-Bromo-2-hydroxypyridine typically involves the regioselective bromination of a precursor like 2-pyridone. Processes often utilize bromine in an aqueous solution, followed by purification steps such as recrystallization from solvents like acetonitrile. Achieving a high yield (often around 78%) and the desired purity (minimum 97%) requires precise control over reaction parameters like temperature, pH, and reagent concentrations. For those looking to buy this compound, ensuring the manufacturer employs robust and scalable synthesis methods is crucial for consistent supply.
Physically, 3-Bromo-2-hydroxypyridine presents as a light yellow to off-white crystalline powder. Its melting point typically falls within the range of 179-189°C. While it exhibits stability under normal conditions, proper storage away from light and incompatible substances is recommended. Its solubility in polar organic solvents makes it amenable to a variety of reaction conditions commonly employed in organic synthesis. These physical properties are important for handling and formulation in downstream processes.
Chemically, the presence of both a bromine atom and a hydroxyl group on the pyridine ring makes 3-Bromo-2-hydroxypyridine a versatile synthon. The bromine atom can readily undergo nucleophilic substitution or participate in metal-catalyzed cross-coupling reactions, while the hydroxyl group can be derivatized or participate in hydrogen bonding. This reactivity profile is central to its role as an intermediate in the synthesis of pharmaceuticals, including the development of pyrazolopyridines.
When considering sourcing this compound, engaging with a reliable supplier is key. A good supplier will not only offer competitive prices but also provide comprehensive product specifications and technical support. Companies in China are well-positioned to serve this need, offering both quality and scale. If you are planning to purchase this important intermediate, we encourage you to request a quote and explore the options available from leading manufacturers.
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