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The Ubiquitin-Proteasome System (UPS) is fundamental to cellular health, regulating protein degradation and various cellular processes. Deubiquitinating enzymes (DUBs), like Ubiquitin C-terminal Hydrolase L3 (UCH-L3), are critical components of this system, responsible for removing ubiquitin chains from target proteins. Dysregulation of UCH-L3 has been linked to several diseases, making it a significant target for pharmacological intervention and research. This is where specialized chemical compounds, such as 4,5,6,7-Tetrachloro-1H-indene-1,3(2H)-dione (TCID), come into play.
TCID is a well-established inhibitor that specifically targets UCH-L3, offering potent activity with an IC50 of 0.6 µM. A key advantage of TCID is its high selectivity, being over 100 times more selective for UCH-L3 than for UCH-L1, another important DUB. This specificity is crucial for researchers who need to isolate the effects of UCH-L3 inhibition without significant interference from other cellular pathways. As a cell-permeable molecule, TCID can effectively enter cells, allowing for in-depth studies of its effects on intracellular protein homeostasis and signaling cascades.
For academic and industrial researchers, acquiring high-quality TCID is a critical step in advancing their studies. When looking to buy TCID, it is important to partner with a reputable TCID supplier that guarantees purity and consistency. Many leading chemical manufacturers, particularly those based in China, are now offering TCID, providing researchers with accessible and affordable options. These suppliers often provide detailed specifications, including chemical structure, purity analysis (e.g., HPLC, NMR), and solubility data, ensuring that scientists receive a reliable product for their experiments.
The research applications of TCID are diverse, ranging from basic cell biology to early-stage drug discovery. Its ability to modulate ubiquitination makes it a valuable tool for investigating disease mechanisms where UPS dysfunction is a factor. For example, studies have explored its role in neurodegenerative diseases by observing its effects on neuronal protein ubiquitination. Researchers can leverage TCID to understand the fundamental roles of UCH-L3 and to identify potential therapeutic strategies. To ensure the success of your research projects, consider sourcing your TCID from a trusted chemical manufacturer that emphasizes quality control and reliable supply chains.
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1. 20 years of R&D, manufacturing and sales experience, serving customers in 60 countries and regions around the world;
2. Own R&D laboratory, pilot platform and large-scale production workshop, which can meet the audit requirements of global customers;
3. We can satisfy customers' perfect transition from small scale lab requirements (gram level) to commercialization requirements (hundred tons level).
A: We don't have Minimum Order Quantity, exact quantity should be provided before quotation for us to calculate the exact cost.
A: We don't provide free samples due to lots of request and expensive international courier's cost, we can deduct the sample charge after commercial order placed.
A: Our payment terms: Small or sample order: T/T IN ADVANCE. Commercial order: First order should be by T/T IN ADVANCE or L/C at sight, and following orders T/T 30~90days is acceptable subject to approval of credit application.
