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Understanding the Chemical Properties and Applications of 2-(4-Bromophenyl)imidazo[1,2-a]pyridine

For scientists and engineers in chemistry-driven industries, a thorough understanding of a compound's properties and its potential applications is key to successful product development. 2-(4-Bromophenyl)imidazo[1,2-a]pyridine (CAS: 34658-66-7) is a prime example of a versatile intermediate whose chemical characteristics lend themselves to a broad spectrum of uses, from pharmaceutical synthesis to advanced material creation.

Chemically, this compound is defined by its molecular formula C13H9BrN2 and a molecular weight of 273.13 g/mol. Its structure features an imidazo[1,2-a]pyridine heterocyclic system, which is a common scaffold in biologically active molecules. The critical addition is the 4-bromophenyl group at the 2-position. The bromine atom serves as a highly useful functional handle, readily participating in palladium-catalyzed cross-coupling reactions such as Suzuki, Sonogashira, and Buchwald-Hartwig couplings. These reactions are cornerstones of modern organic synthesis, allowing for the precise introduction of complex substituents and the construction of elaborate molecular architectures.

The physical properties of 2-(4-Bromophenyl)imidazo[1,2-a]pyridine are also noteworthy. It is typically supplied as an off-white to light yellow powder with a melting point in the range of 216-220°C. Its solubility in certain organic solvents, like ethanol, as indicated by its λmax value, further informs its handling and reaction suitability. Manufacturers often specify a minimum purity of 97% (HPLC), which is essential for consistent experimental outcomes.

The applications stemming from these properties are diverse. In medicinal chemistry, it acts as a vital intermediate for synthesizing drug candidates, especially those targeting cancer and neurological disorders. Its ability to undergo facile functionalization allows researchers to tailor molecular properties for enhanced efficacy and specificity. In materials science, it contributes to the development of organic electronic materials, fluorescent dyes, and sensors, leveraging its electronic and photophysical characteristics.

For those seeking to purchase this compound, reliable suppliers in China offer this intermediate, ensuring that researchers and manufacturers can access its valuable properties for their groundbreaking work. Understanding these chemical and physical attributes empowers scientists to effectively utilize 2-(4-Bromophenyl)imidazo[1,2-a]pyridine in their synthetic strategies, driving innovation across various industries.

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