In the realm of fine chemicals and pharmaceutical intermediates, a deep understanding of a compound's chemical properties and synthesis is crucial for effective application and procurement. 2-(2-(Piperazin-1-yl)ethoxy)ethanol, identified by CAS number 13349-82-1, is a prime example of such a compound, widely recognized for its utility in complex organic synthesis, particularly within the pharmaceutical industry.

Chemical Profile of 2-(2-(Piperazin-1-yl)ethoxy)ethanol
This N-alkylpiperazine derivative boasts a molecular formula of C8H18N2O2 and a molecular weight of 174.24 g/mol. It typically presents as a clear, colorless to yellow-brownish liquid, with a density of approximately 1.061 g/mL at 25°C and a refractive index of around 1.497 (n20/D). Its boiling point is noted as 112-114°C at 0.25 mmHg. The compound exhibits moderate solubility in solvents like acetone, chloroform, and methanol. These physical and chemical properties are vital for chemists and procurement specialists to consider when planning synthesis routes or evaluating potential suppliers. Knowing these details helps in determining compatibility with other reagents and appropriate storage conditions.

Synthesis Pathways and Considerations
Several methods exist for the synthesis of 2-(2-(Piperazin-1-yl)ethoxy)ethanol. One common approach involves the reaction of piperazine with 2-(2-chloroethoxy)ethanol. Another described method utilizes piperazine and a protected form of the ethoxyethanol derivative, followed by deprotection. For instance, a documented synthesis involves reacting a precursor with trifluoroacetic acid in dichloromethane, followed by neutralization with sodium hydroxide. Yields can be high, often reported around 95%, underscoring the efficiency of optimized synthetic routes. Companies looking to purchase this intermediate often inquire about the synthesis methods to ensure it aligns with their own quality and regulatory standards.

Applications and Importance in Pharmaceutical Manufacturing
The primary application driving the demand for 2-(2-(Piperazin-1-yl)ethoxy)ethanol is its role as a key intermediate in the synthesis of Quetiapine, an important antipsychotic medication. Its specific structure provides essential molecular fragments required for building the Quetiapine molecule. For pharmaceutical manufacturers, securing a consistent supply of high-purity 2-(2-(Piperazin-1-yl)ethoxy)ethanol from a reliable chemical manufacturer in China is paramount. This ensures not only the efficiency of their API production but also the quality and safety of the final drug product.

Partnering with NINGBO INNO PHARMCHEM CO.,LTD.
NINGBO INNO PHARMCHEM CO.,LTD. is a leading provider of high-quality pharmaceutical intermediates. As a dedicated supplier of 2-(2-(Piperazin-1-yl)ethoxy)ethanol, we offer products with proven purity and well-documented synthesis processes. Our commitment to research and development, coupled with our robust manufacturing capabilities, allows us to meet the exacting standards of the global pharmaceutical industry. We encourage procurement managers and R&D scientists to explore our offerings and to request a quote for their chemical needs. By choosing NINGBO INNO PHARMCHEM, you gain a partner committed to delivering quality and reliability in every shipment.

For those looking to buy 2-(2-(Piperazin-1-yl)ethoxy)ethanol, understanding its chemical properties and reliable synthesis methods is key. NINGBO INNO PHARMCHEM CO.,LTD. is well-positioned to be your trusted source for this critical pharmaceutical intermediate.